Skip to main content

Lost Rebuttal from Dr. Ena

Dr. Ena Valikov is a Veterinarian from Huntington Beach, CA.  She frequently comments on posts, usually those regarding transgenic technologies, and presents coherent arguments that elevate the discussion.  She has a background in biochemistry so she speaks science well and can discuss the literature.

Yesterday morning my gmail account posted several responses to my September 21 post. There were two there from Dr. Ena.  I was excited to read them and prepare my responses. Yet when I looked at the comment section of the article one of her comments was not there.  Instead, there was an appropriately cynical comment from Dr. Ena about censoring the comments.

I have no idea what happened or where her comment disappeared to.  However, I was disappointed and upset for several reasons.  First, I appreciate an informed rebuttal because I am the first to admit, I might be wrong.  I'm glad to consider all evidence in my synthesis.  Second, I would never, and have never censored a comment. On one of my YouTube posts someone made rude and offensive comments about one of my student's foreign accents.  I left it, and pointed out its ignorance. This is a marketplace of ideas and to be a censoring or dismissive gatekeeper is the stuff of activism, not science.

I'm posting here Dr. Ena's lost comment.  I can't seem to find her as I don't have her actual email address, so I hope this is acceptable (I'll take this down if you don't want it posted, Ena).  I just feel awful, I don't like how it taints the perception of communication in this forum.

So here I post Dr. Ena's points in response to my Sept 21 post, and her arguments supporting Seralini's recent work.  My comments will appear below in the Comments section.

Ena Valikov has left a new comment on your post "Rats, Tumors and Critical Assessment of Science": 

(KF) Ena, a replicated study would be great, unfortunately Seralini's stuff never is replicated.
Meaning that you don't have a single LONG TERM STUDY examining laboratory animals for Long Term Chronic effects.

No, I don't think this study is trash, because I know mammary tumors to be estrogen sensitive. The study demonstrated elevated estradiol levels in both males and females and even proposed a mechanism of action by which EPSPS can alter estradiol levels. 

As to the control groups and experimental group : why is there a study on biofortified composed of 15 rats, which none of you objected to?
Prima facie evidence that a phytocystatin for transgenic plant resistance to nematodes is not a toxic risk in the human diet.

It is a study on 15 rats fed purified extract rather then the genetically modified rice… and the only biochemical/ hematological patient data actually published is

Summary of results from the toxicological study of male Sprague-Dawley rats administered the cystatin OcIΔD861

OcIΔD86 [mg/(kg · d)]
0 0.1 1 10
Food intake, g
    d 3–7 25.04 ± 0.94 25.80 ± 0.90 26.82 ± 1.48a 25.36 ± 1.42
    d 7–10 26.06 ± 0.40 25.68 ± 1.32 27.74 ± 1.43a 25.82 ± 0.98
Organ weight
    Cecum (empty), g 0.305 ± 0.033 0.334 ± 0.057 0.32 ± 0.013 0.35 ± 0.041a
    Liver, g 3.12 ± 0.16 3.00 ± 0.072a 3.02 ± 0.090a 3.04 ± 0.12
Serum analysis
    Potassium, mmol/L 4.51 ± 0.27 4.78 ± 0.318 4.66 ± 0.251 4.95 ± 0.82a
    Urea, mmol/L 6.58 ± 0.82 5.61 ± 0.67b 6.09 ± 0.616 6.24 ± 0.887
    Creatinine, μmol/L 39.0 ± 2.83 39.7 ± 3.02 41.0 ± 1.66 41.5 ± 3.21a
    γ-Glutamyl transferase, U/L 0.07 ± 0.067 0.42 ± 0.67a 0.13 ± 0.11 0.18 ± 0.13

Here is what a blood panel should actually look like:
Test Result Reference Range
ALT (SGPT) 57 5 – 107 U/L
AST (SGOT) 25 5 – 55 U/L
CK 171 10 – 200 U/L
GGT 4 0 – 14 U/L
AMYLASE 344 450 – 1240 U/L LOW
LIPASE 397 100 – 750 U/L
ALBUMIN 3.9 2.5 – 4.0 g/dL
TOTAL PROTEIN 8.4 5.1 – 7.8 g/dL HIGH
GLOBULIN 4.5 2.1 – 4.5 g/dL
TOTAL BILIRUBIN 0.2 0.0 – 0.4 mg/dL
DIRECT BILIRUBIN 0.1 0.0 – 0.2 mg/dL
BUN 34 7 – 27 mg/dL HIGH
CREATININE 1.2 0.4 – 1.8 mg/dL
CHOLESTEROL 336 112 – 328 mg/dL HIGH
GLUCOSE 131 60 – 125 mg/dL HIGH
CALCIUM 11.0 8.2 – 12.4 mg/dL
PHOSPHORUS 8.3 2.1 – 6.3 mg/dL HIGH
TCO2 (BICARBONATE) 25 17 – 24 mEq/L HIGH
CHLORIDE 87 105 – 115 mEq/L LOW
POTASSIUM 4.3 4.0 – 5.6 mEq/L
SODIUM 144 141 – 156 mEq/L
A/G RATIO 0.9 0.6 – 1.6
B/C RATIO 28.3
INDIRECT BILIRUBIN 0.1 0 – 0.3 mg/dL
TRIGLYCERIDE 98 20 – 150 mg/dL
NA/K RATIO 33 27 – 40
ANION GAP 36 12 – 24 mEq/L HIGH

WBC 26.7 5.7 – 16.3 K/uL HIGH
RBC 8.03 5.5 – 8.5 M/uL
HGB 19.1 12 – 18 g/dL HIGH
HCT 52.0 37 – 55 %
MCV 65 60 – 77 fL
MCH 23.8 19.5 – 26.0 pg
MCHC 36.7 32 – 36 g/dL HIGH
MONOCYTES 11 3 – 10 % HIGH
BASOPHIL 0 0 – 1 %
AUTO PLATELET 725 164 – 510 K/uL HIGH

ABSOLUTE NEUTROPHIL SEG 21360 3000 – 11500 /uL
ABSOLUTE LYMPHOCYTE 1068 1000 – 4800 /uL
ABSOLUTE MONOCYTE 2937 150 – 1350 /uL

Test Result Reference Range
T4 (1) 2.5 1.0 – 4.0 ug/dL

The study’s limitations are quite obvious: its duration is 21 days and N=15, not to mention that the rats weren’t fed the genetically engineered rice, but rather the isolated protein (which is not equivalent to the whole food).

Can you please explain how findings in 15 rats fed this GMO for 21 days imply safety in millions of people, eating the stuff for decades?

Because from my vantage point, the only time you really care about control group size, or statistics--is when a study comes out suggestive of long term harm. You know ... the kind you would never catch, if you only study the GMO for the required 90 days. 

Posted by Ena Valikov to Illumination at September 21, 2012 10:47 PM

Popular posts from this blog

Scientific American Destroys Public Trust in Science

This is a sad epitaph, parting words to an old friend that is now gone, leaving in a puff of bitter betrayal. 
When I was a kid it was common for my mom to buy me a magazine if I was sick and home from school.  I didn't want MAD Magazine or comic books.  I preferred Scientific American
The once stalwart publication held a unique spot at the science-public interface, bringing us interesting and diverse stories of scientific interest, long before the internet made such content instantly accessible.  It was our trusted pipeline to the new edges of scientific discovery, from the mantle of the earth to the reaches of space, and every critter in between.
But like so much of our trusted traditional science media, Scientific American has traded its credibility for the glitz of post-truth non-scientific beliefs and the profits of clickbait.The problem is that when a trusted source publishes false information (or worse, when it hijacked by activists) it destroys trust in science, trust in s…

Chipotle's Ag-vertising to Fix their Anti-Ag Image

After years of anti-farmer rhetoric, disgusting anti-agriculture videos, and trashing farmer seed choice, Chipotle now seems to have found a love for the American farmer that is as warm and inviting as the gooey core of a steak burrito.  Their new "Cultivate the Future of Farming" campaign raises awareness of the hardship being experienced in agriculture, and then offers their thoughts and some seed grants in order to reverse it. 

But are they solving a problem that they were instrumental in creating? 

The crisis in agriculture is real, with farmers suffering from low prices, astronomical costs, and strangling regulation.  Farmer suicides are a barometer of the crisis.  Farms, from commodity crops to dairies, are going out of business daily. It is good to see a company raising awareness. 

From Chipotle's website- The "challenge is real" and "It's a hard living"-- and companies like Chipotle were central in creating those problems. 

However, Chipotle&#…

Mangling Reality and Targeting Scientists

Welcome to 2019, and one thing that remains constant is that scientists engaging the public will continue to be targeted for harassment and attempted reputation harm.  

The good news is that it is not working as well as it used to.  People are disgusted by their tactics, and only a handful of true-believers acknowledge their sites as credible. 

But for those on the fence I thought it might be nice to post how a website like SourceWatch uses a Wikipedia-mimic interface to spread false and/or misleading information about public scientists. 

Don't get me wrong, this is not crying victim.  I'm actually is screaming empowerment.  I spent the time to correct the record, something anyone can check.  Please look into their allegations and mine, and see who has it right. 

This is published by the Center for Media and Democracy.  Sadly, such pages actually threaten democracy by providing a forum for false information that makes evidence-based decisions in policy issues more challenging.  It…