Sunday, September 23, 2012

Lost Rebuttal from Dr. Ena

Dr. Ena Valikov is a Veterinarian from Huntington Beach, CA.  She frequently comments on posts, usually those regarding transgenic technologies, and presents coherent arguments that elevate the discussion.  She has a background in biochemistry so she speaks science well and can discuss the literature.

Yesterday morning my gmail account posted several responses to my September 21 post. There were two there from Dr. Ena.  I was excited to read them and prepare my responses. Yet when I looked at the comment section of the article one of her comments was not there.  Instead, there was an appropriately cynical comment from Dr. Ena about censoring the comments.

I have no idea what happened or where her comment disappeared to.  However, I was disappointed and upset for several reasons.  First, I appreciate an informed rebuttal because I am the first to admit, I might be wrong.  I'm glad to consider all evidence in my synthesis.  Second, I would never, and have never censored a comment. On one of my YouTube posts someone made rude and offensive comments about one of my student's foreign accents.  I left it, and pointed out its ignorance. This is a marketplace of ideas and to be a censoring or dismissive gatekeeper is the stuff of activism, not science.

I'm posting here Dr. Ena's lost comment.  I can't seem to find her as I don't have her actual email address, so I hope this is acceptable (I'll take this down if you don't want it posted, Ena).  I just feel awful, I don't like how it taints the perception of communication in this forum.

So here I post Dr. Ena's points in response to my Sept 21 post, and her arguments supporting Seralini's recent work.  My comments will appear below in the Comments section.

Ena Valikov has left a new comment on your post "Rats, Tumors and Critical Assessment of Science": 

(KF) Ena, a replicated study would be great, unfortunately Seralini's stuff never is replicated.
Meaning that you don't have a single LONG TERM STUDY examining laboratory animals for Long Term Chronic effects.

No, I don't think this study is trash, because I know mammary tumors to be estrogen sensitive. The study demonstrated elevated estradiol levels in both males and females and even proposed a mechanism of action by which EPSPS can alter estradiol levels. 

As to the control groups and experimental group : why is there a study on biofortified composed of 15 rats, which none of you objected to?
Prima facie evidence that a phytocystatin for transgenic plant resistance to nematodes is not a toxic risk in the human diet.http://www.ncbi.nlm.nih.gov/pubmed/14747684

It is a study on 15 rats fed purified extract rather then the genetically modified rice… and the only biochemical/ hematological patient data actually published is

TABLE 1
Summary of results from the toxicological study of male Sprague-Dawley rats administered the cystatin OcIΔD861

OcIΔD86 [mg/(kg · d)]
0 0.1 1 10
Food intake, g
    d 3–7 25.04 ± 0.94 25.80 ± 0.90 26.82 ± 1.48a 25.36 ± 1.42
    d 7–10 26.06 ± 0.40 25.68 ± 1.32 27.74 ± 1.43a 25.82 ± 0.98
Organ weight
    Cecum (empty), g 0.305 ± 0.033 0.334 ± 0.057 0.32 ± 0.013 0.35 ± 0.041a
    Liver, g 3.12 ± 0.16 3.00 ± 0.072a 3.02 ± 0.090a 3.04 ± 0.12
Serum analysis
    Potassium, mmol/L 4.51 ± 0.27 4.78 ± 0.318 4.66 ± 0.251 4.95 ± 0.82a
    Urea, mmol/L 6.58 ± 0.82 5.61 ± 0.67b 6.09 ± 0.616 6.24 ± 0.887
    Creatinine, μmol/L 39.0 ± 2.83 39.7 ± 3.02 41.0 ± 1.66 41.5 ± 3.21a
    γ-Glutamyl transferase, U/L 0.07 ± 0.067 0.42 ± 0.67a 0.13 ± 0.11 0.18 ± 0.13

——————————————————————————————
Here is what a blood panel should actually look like:
Test Result Reference Range
ALK. PHOSPHATASE 294 10 – 150 U/L HIGH
ALT (SGPT) 57 5 – 107 U/L
AST (SGOT) 25 5 – 55 U/L
CK 171 10 – 200 U/L
GGT 4 0 – 14 U/L
AMYLASE 344 450 – 1240 U/L LOW
LIPASE 397 100 – 750 U/L
ALBUMIN 3.9 2.5 – 4.0 g/dL
TOTAL PROTEIN 8.4 5.1 – 7.8 g/dL HIGH
GLOBULIN 4.5 2.1 – 4.5 g/dL
TOTAL BILIRUBIN 0.2 0.0 – 0.4 mg/dL
DIRECT BILIRUBIN 0.1 0.0 – 0.2 mg/dL
BUN 34 7 – 27 mg/dL HIGH
CREATININE 1.2 0.4 – 1.8 mg/dL
CHOLESTEROL 336 112 – 328 mg/dL HIGH
GLUCOSE 131 60 – 125 mg/dL HIGH
CALCIUM 11.0 8.2 – 12.4 mg/dL
PHOSPHORUS 8.3 2.1 – 6.3 mg/dL HIGH
TCO2 (BICARBONATE) 25 17 – 24 mEq/L HIGH
CHLORIDE 87 105 – 115 mEq/L LOW
POTASSIUM 4.3 4.0 – 5.6 mEq/L
SODIUM 144 141 – 156 mEq/L
A/G RATIO 0.9 0.6 – 1.6
B/C RATIO 28.3
INDIRECT BILIRUBIN 0.1 0 – 0.3 mg/dL
TRIGLYCERIDE 98 20 – 150 mg/dL
NA/K RATIO 33 27 – 40
HEMOLYSIS INDEX (1) N
LIPEMIA INDEX (2) N
ANION GAP 36 12 – 24 mEq/L HIGH

WBC 26.7 5.7 – 16.3 K/uL HIGH
RBC 8.03 5.5 – 8.5 M/uL
HGB 19.1 12 – 18 g/dL HIGH
HCT 52.0 37 – 55 %
MCV 65 60 – 77 fL
MCH 23.8 19.5 – 26.0 pg
MCHC 36.7 32 – 36 g/dL HIGH
NEUTROPHIL SEG 80 60 – 77 % HIGH
NEUTROPHIL BANDS 5 0 – 3 % HIGH
LYMPHOCYTES 4 12 – 30 % LOW
MONOCYTES 11 3 – 10 % HIGH
EOSINOPHIL 0 2 – 10 % LOW
BASOPHIL 0 0 – 1 %
AUTO PLATELET 725 164 – 510 K/uL HIGH
PLATELET COMMENTS
PLATELETS APPEAR INCREASED.

ABSOLUTE NEUTROPHIL SEG 21360 3000 – 11500 /uL
ABSOLUTE NEUTROPHIL BAND 1335 0 – 300 /uL
ABSOLUTE LYMPHOCYTE 1068 1000 – 4800 /uL
ABSOLUTE MONOCYTE 2937 150 – 1350 /uL
ABSOLUTE EOSINOPHIL 0 100 – 1250 /uL
ABSOLUTE BASOPHIL 0 0 – 100 /uL

SENIOR PROFILE W/ TRIG : T4
Test Result Reference Range
T4 (1) 2.5 1.0 – 4.0 ug/dL


The study’s limitations are quite obvious: its duration is 21 days and N=15, not to mention that the rats weren’t fed the genetically engineered rice, but rather the isolated protein (which is not equivalent to the whole food).

Can you please explain how findings in 15 rats fed this GMO for 21 days imply safety in millions of people, eating the stuff for decades?

Because from my vantage point, the only time you really care about control group size, or statistics--is when a study comes out suggestive of long term harm. You know ... the kind you would never catch, if you only study the GMO for the required 90 days. 



Posted by Ena Valikov to Illumination at September 21, 2012 10:47 PM


88 comments:

Kevin M. Folta said...

Ena, Let's get right to your question on the bottom of the page:

Can you please explain how findings in 15 rats fed this GMO for 21 days imply safety in millions of people, eating the stuff for decades?

The study was not designed to justify feeding transgenic food to people. The study was from Howard Atkinson, the world authority in cystains (protease inhibitors that can affect nematode -and other pest- digestion).

Atkinson and colleagues have performed many tests on cystatin mechanism of action, efficacy in the lab as an anti-nematode agent, and even environmental impacts of the transgene.

The goal of this study was to test if there was any sign of harm in animals from consumption of the agent. It was not a test to conclusively show that this was great to feed babies.

It also was not performed in a commercialized transgenic food. In fact, cystatins are still not used in transgenic plants commercially.

The first words of the title say Prima facia, admitting up front that this is a first look, a pilot test in a new area of research. No evidence of harm was observed in these conditions. This is important because if there was a problem it is best caught early in a small study.

On the other hand, Seralini et al present an argument to overturn an industry. As revealed by their conference call and the verbiage of their text, they claim a conclusive, final, solid link between GMOs and tumors in SD rats. This extraordinary claim requires extraordinary evidence, large numbers, proper statistics, and no hidden controls.

As a scientific reviewer we have to ask first, what is the hypothesis being tested? Are the experiments appropriate to test they hypothesis? Do the data and statistical treatments reject or support the hypothesis?

Atkinson's paper does this. Seralini's does not.

That is the difference between the two papers, even though both show no compelling evidence of harm.

Kevin M. Folta said...

I just found this, thought it was excellent.

"Forbes notes one independent academic source pleased to see the Seralini work. The Statistical Laboratory at the University of Cambridge was "grateful for the authors for publishing this paper, as it provides a fine case study for teaching a statistics class about poor design, analysis and reporting." Adding they "shall start using it immediately."

Ena Valikov said...

Epigenetic Events Associated with Breast Cancer and Their Prevention
by Dietary Components Targeting the Epigenome
Shabana I. Khan,†,‡ Pranapda Aumsuwan,†,§ Ikhlas A. Khan,†,‡,|| Larry A. Walker,†,§,^ and
Asok K. Dasmahapatra

caffeic acid partially inhibited the methylation of RARβ
promoter/MCF-7, MDA-MB-23197
RARβ/MCF-7,
MDA-MB-23197


http://pubs.acs.org/doi/pdf/10.1021/tx200378c

dogctor@yahoo.com

:)

Ena Valikov said...

Roles of microRNAs in breast cancer
Over the past few years, miRNA profiling studies have led to the identification of miRNAs that are aberrantly expressed in human breast cancer. The function of only a handful of these miRNAs in breast cancer has been investigated. As in other cancers, some miRNAs can function as tumor suppressors and other miRNAs as oncogenes. Thus, tumor formation may arise from a reduction or deletion of a tumor suppressor miRNA and/or amplification or overexpression of an oncogenic miRNA. In addition, tumor metastasis may be promoted by enhanced expression of prometastatic and/or downregulation of antimetastatic miRNAs. The functions of these miRNAs in breast tumor progression and metastasis are discussed below.

http://breast-cancer-research.com/content/12/2/201

PS: the fist very long post disappeared in the internet vapor, again!

Ena Valikov said...

So, Kevin-- your blog has eaten a pretty long response TWICE.

It showed up for a few minutes, twice and then disappeared--twice.

Tired of playing.

And the robo-captions are impossible to read, to boot.

Ena Valikov said...

You are still NOT censoring, COMRADE?

Pathetic, really!

Ena Valikov said...

Rebuttal 2.0. Kevin.


http://www.science20.com/science_20/blog/gm_maize_causes_tumors_rats_here_how_experts_responded-94259#comment-123041

Kevin Folta said...

Hi Ena, first, thanks for being a good sport and participating again. I honestly don't know what happened.

Unfortunately I'm completely slammed at the moment. I'd love to respond, but it won't be until Saturday! I will address your points. Thanks.

Michael said...

"You are still NOT censoring, COMRADE?

Pathetic, really!"

Kevin, why you continue to engage this person is beyond me, you pathetic communist.

Ena Valikov said...

Ena Valikov ena1101961@gmail.com
5:39 PM (17 hours ago)

to Kevin
It's cool Kevin. I know what it's like being busy- don't sweat it.

I look forward to your response when you have time.

Cheers,

Ena



http://www.youtube.com/watch?v=JmcA9LIIXWw

and oldie but goodie ;-)

Kevin M. Folta said...

Ena, I'm absolutely not censoring. I don't know what is happening. If you endure the hassle of copy/paste of your responses and email them to me I'll be glad to post them for discussion.

Ena Valikov said...

Part 1/2
Can you please explain how findings in 15 rats fed this GMO for 21 days imply safety in millions of people, eating the stuff for decades?

The answer to the question is “ it can't".


The points are simple:
There is not a single valid blinded long term clinical controlled feeding trial in the literature.


The second point is that if you are going to criticize Seralini, you might want to apply the same standards of logical and scientific consistency. Plucking the Only long term trial on record in the history of OECD biotechnology regulation ( which in spite of all its flaws the study satisfied) and criticizing the control group, while staying mum about the similarly grossly unbalanced statistics of the GMO study cited below. There are bloggers who are critical of it because it isn't blinded, while there is not a Single blinded GMO safety study Anywhere in the literature.

Extraordinary claims deserve extraordinary evidence except where SAFETY ASSURANCE STUDIES by Hammond et al. are concerned. Assuring us that the crap is safe for millions to eat for generations is an extraordinary claim backed by No evidence at all. When 90 day rodent tests ( based on OECD regulations no one complained about in the past), some of which are performed on 400 rats of which there are 80 experimental animals, of whom partial data is published for 10-20, ya might as well just call the evidence “ oh hell, just trust me”.

Results of a 90-day safety assurance study with rats fed grain
from corn rootworm-protected corn
B. Hammond a,*, J. Lemen a, R. Dudek a, D. Ward a, C. Jiang a, M. Nemeth a, J. Burns b
a Monsanto Company, 800 North Lindbergh Blvd., St Louis, MO 63167, United States
b Covance Laboratories, Inc., 9200 Leesburg Pike, Vienna, VA 22182-1699, United States
Received 1 June 2005; accepted 22 June 2005

And I don't see anything addressing this fact on biofortifiedd, where it turns out there isn't a single long term controlled feeding trial satisfying even basic medical standards is to be found, just like the rest of literature. Please cite One.


Did Serallini show long term harm? you betcha! The rats fed GE corn or GE corn with Round Up, or Round Up died before the controls (Figure 1)

Is it statistically significant?

Unlikely without a single p-value reported in the entire study. However, previous studies already documented kidney and liver pathology, making the shorter life-span not even remotely surprising. The breast cancer finding is a complicated one because there are dozens of pathways and feedbacks that drive breast cancer – estrogen, estrogen receptors and antagonists, aromatase inhibitors and so on. In a world without politicized science one would start by replicating the estradiol levels reported in rodents fed the transgenic corn since estradiol is mitogenic and examining whether the overexpression of ESPS could be driving synthesis of other aromatic estrogenic metabolites.

Ena Valikov said...

Part 2/2

Finally microRNA's. Karl at biofortified began the censorship game months ago. I admit that my email to him wasn't fuzzy and nice, but the censorship started when I wished to discuss the implications of the rice miRNA study. The ideas propagated at biofortified are so fragile, hatched by scientists so thin- skinned, that he might as well be guarding the delicate things in a medieval castle behind an alligator-filled-moat.

Do I realize we have been eating microRNAs for millennium? You betcha.

Does that mean I should be comfortable with rushing engineering plants (some of whom might be deploying this new knock-out technology) without thorough controlled feeding trials and without publishing sequences of novel mi RNA created by transgenic technology? The rice mi RNA study changes old paradigms. Acknowledging that a study which documented that plant miRNAs aren't digested, are absorbed into the blood stream and are regulating genes across kingdoms, including human organs, should lead to re-thinking the old rules such as EPSPS is a bacterial-plant enzyme catalyzing a metabolic pathway wich doesn't exist in humans, therefore it can't possibly do anything to a mammal... not true anymore.
When classical insect miRNA are found to play a role in Human breast cancer.
let-7f, a tumor-suppressor mi RNA which targeted the aromatase gene (CYP19A1) expression.
http://www.ncbi.nlm.nih.gov/pubmed/22407818. the old paradigms such as Bt is a toxin specific to insect guts can not affect mammalian guts lacking those specific receptors....likewise needs to change.
You might engineer neutraceutical, medicinal miRNAs or oncogenic miRNA. The old " don't look, don't tell" wont work. There are too many miRNA's playing a role in breast cancer as well as all sorts of diseases to feel comfortable stating with certainty that there is no mechanism ( endocrine or epigenetic)by which the trangenic corn can not raise rates of breast cancer.

And since you dedicated a blog to me, and I love music--here is one you might not have heard before ( no gambling in this one) some say to forward to 1.08min
http://www.youtube.com/watch?v=0YTh1Wsqo2c


Ena

Kevin Folta said...

Ena, I just don't get your veracity in defense of this work. Now that this has blossomed to allegations of scientific misconduct and fraud, many scientists, even those not engaged in the GMO discussion are now tearing this thing to pieces. I'll address your points, but I'll tell you up front, you spend too much time with misdirection. My original post was about the Seralini paper and a scientific post-hoc criticism of points missed by other analyses. But I'll work laterally to touch your points.

There are no reports that show GMO safety, because science cannot prove that something, anything, is safe. We can only show evidence of harm using a given model and set of tests, over a given time. That’s it. You keep bringing up safety. Do they ever test any new variety, organic culture system, novel hybrid for evidence of harm? Never.

>>> The second point is that if you are going to criticize Seralini…

I’ll have to look at the Hammond paper. If there’s something wrong with it I’ll put it up next time. However, my analysis of Seralini’s work stands on its own. It’s clear agenda and intent are deplorable. That’s my point. That stands regardless of what others publish before/after.

>>>>Extraordinary claims deserve extraordinary evidence….

Again, nobody says it is safe, just evidence of harm. I’m itchy to see Hammond. I’m not at work now, so I can’t access. However, I’d be surprised if they say it is “safe” and if they do they are wrong. Again, this shows your bias. Breeding programs NEVER test new varieties, despite moving thousands of genes. No safety assessment, because it is impossible to test everything. There is no plausible mechanism for harm, and no evidence of harm.

>>>And I don't see anything addressing this fact on biofortified….

Here’s the problem. You want some long-term study to show something is safe. What is “safe”? What does that mean? If someone spent millions of dollars to hire postdocs and do the experiment to test that GM is dangerous, what are the endpoints? What do you measure? Who would fund this with no preliminary data showing harm and no plausible mechanism that can suggest harm? No funding agency would fund such trash. That’s not science, that’s paranoia. Plus, if they did it and tested a dozen metrics, you’d still say they didn’t do enough… because you can’t prove something is safe. There always will be another reason to complain about studies that weren’t done.

>>>>Did Serallini show long term harm? you betcha! The rats fed GE corn or GE corn with Round Up, or Round Up died before the controls (Figure 1)

Ena, the fact that you are compelled by the Seralini paper shows that you have made up your mind, and know nothing about experimental design. You betcha? If I flip a coin and it comes up heads three times in a row, can we conclude that the coin has a “head” on both sides? Maybe according to you and Seralini. The data are meaningless if the experimental design is inadequate. Period.

>>>Is it statistically significant?

NO. It Is not. And you can’t say that previous reports from the same lab reinforce this. If someone else, anyone other than the lab in an anti-GMO institute where the lead author sells books and movies and his results are never replicated outside of his own lab… not compelling.
And when controls are not show, eg. Figure 3, it really exposes intent.


>>>> estradiol is mitogenic and examining the overexpression of ESPS could be driving synthesis of other aromatic estrogenic metabolites.

But they can’t just hand-wave and then it is so. Maybe you buy it, but scientists like me have an evidence threshold. You have to show it. Do the experiment. This is why this paper is in a low-caliber journal.

Kevin Folta said...

Ok, your second comments.

>>>Finally microRNA's. Karl at biofortified began the censorship,,,,

I know Karl pretty well. He’s a good guy, super knowledgeable and a solid scientist. I doubt there was censorship, meaning that he was suppressing ideas. I don’t know. I hope you are not implying that I am not giving you a fair forum.

>>>>Do I realize we have been eating microRNAs for millennium? You betcha.

More than a millennium... try since the dawn of eukaryotes probably. First, the rice miRNA study is a year old and no follow ups have come out. That bothers me. I thought it was a really cool paper and neat idea, but had some questions. I hoped that this would open a new area of science and cross-kingdom interaction/signaling. That would have been great.

However, as of right now, it does NOT “change paradigms”. Even if it is 100% true, then why would transgenic food be the target? Plants make natural antisense RNAs, so do fungi. Plants might make more of them when grown hydroponically, or when sprayed with rotenone in an organic plot. Plants might make more of them if the products are hot, refrigerated, not fertilized enough, fertilized too much…. THE POSSIBILITIES ARE ENDLESS! So instead of getting upset about transgenics, get upset about food. As soon as you are calling for the testing of everything then we can talk about singling out a technology.

And the food you eat is not sterile. You consume bacterial and fungal RNA every day by the bucket and none of that has ever been tested. Moreover, the miRNA content of the blood has been well characterized—literally hundreds of papers. In all of these surveys why are dietary/bacteria/fungal miRNAs not found? I dunno. Maybe only that one survives digestion and is detectable in the serum. In other words, it is not a complex soup of plant miRNA.

>>>>When classical insect miRNA are found to play a role in Human breast cancer.

Let7f an insect miRNA? Not according to the reference you cited. It showed that aromatase inhibitors used in breast cancer therapies induce Let7f in vitro and it decreases aromatase levels. Even if there is a same-sequence miRNA in insects, how does it get into humans at levels that are pharmacologically relevant?

>>>>. the old paradigms such as Bt is a toxin specific to insect guts can not affect mammalian guts lacking those specific receptors....likewise needs to change.

Why? You have evidence to the contrary?

>>>> You might engineer neutraceutical, medicinal miRNAs or oncogenic miRNA. The old " don't look, don't tell" wont work. There are too many miRNA's playing a role in breast cancer as well as all sorts of diseases.....

Ena, sure, that’s a testable hypothesis. But why do you just target trangenics? Bt is one sequence. Are you against Bt being used directly on organic crops? Probably not. You can jam the Bt sequence through a number of programs and it will tell you if it even makes miRNAs. I’ll do that. But if you feel that dietary RNA can somehow be processed, transported and sequestered in physiologically relevant levels, then the burden of proof is on you, not me. It is just kooky. I can dream up longshot ideas, I do every day. But even this would be unfundable by any agency without significant preliminary findings.

The Dire Straits song you posted was an instrumental and there were no words at 1:08.

Ena Valikov said...

Quickie Kevin, cause it is the beginning of the month and I've got bills and payroll to deal with, on top of the doctoring. Will be back later in the week to follow up.

(Ena, I just don't get your veracity in defense of this work.)
I am a truth seeker operating on this basic premise, like all medical professionals are:
Primum non nocere
From Wikipedia, the free encyclopedia
Primum non nocere is a Latin phrase that means "first, do no harm".

(Now that this has blossomed to allegations of scientific misconduct and fraud, many scientists, even those not engaged in the GMO discussion are now tearing this thing to pieces)

If they want to see fraud they should read all the Hammond papers.

400 rats, results reported for 10-20, crucial data is absent, pathological conclusions are : nephropathy and hepatobiliary disease in under 90 days.

Isolating the only long term feeding trial without comparing it to the literature titled : SAFETY ASSURANCE Study, would be twisted warped spin, rather than genuine science.

{science cannot prove that something, anything, is safe} science can certainly compare effects on metabolic organs, estradiol levels, upregulation and down regulation of proteins and genes in metabolic organs of subjects ingesting the stuff.....and show it to be as safe, less safe or equally as safe.

Do you have such as controlled blinded long term feeding trial on rats, cats, dogs, or people?

What long term scientific evidence do you actually have demonstrating the transgenic crop's effects in the experimental subjects ingesting it?


>>>> estradiol is mitogenic and examining the overexpression of ESPS could be driving synthesis of other aromatic estrogenic metabolites.<
But they can’t just hand-wave and then it is so. Maybe you buy it, but scientists like me have an evidence threshold.

This is where your myopia shows. Cats, dogs and people do not synthesize aromatic branched chain amino acids. If there is an alternative pathway through which this transgene interacts with your endocrine system--and you discover the mechanism, and engage your " glass is half full" part of the brain, you might see an entry point of intervention to reduce rates of breast cancer or other chronic maladies. At that point I'll help you sell the food.

Plants contain miraculous compounds we could use more of.... why not focus on that?


{But why do you just target trangenics?} I do not target transgenic. I target dishonest scientists.
I've got human recombinant insulin and interferon in my frige at the hospital. They are clearly labeled as products of transgenic technology. Same with erythropoietin we use on cats with kidney disease, same with Filgastrim used on patients with myelodepression due to chemotherapy.

I am not a square peg to be pounded into a round hole.


{ You can jam the Bt sequence through a number of programs and it will tell you if it even makes miRNAs.} I would rather you jam the entire EPSPS transgene with all its bacterial, viral, petunia components into that computer, along with all the flanking sequences adjoining however- many copies were inserted, and compare them to the miRNAs associated with branched chain aromatic amino acids and miRNA involved with estrogen receptors, aromatase inhibitors, or other mechanisms promoting of breast cancer. I lost a friend to breast cancer-- one of the most inspiration people I know. You, Kevin, could be on the side of history reducing breast cancer rates, or on the side potentially increasing it. Which do you see yourself on?

See you.

Another great song to inspire you to be on the side of science that helps women not suffer from breast cancer.
http://www.youtube.com/watch?v=BdDD9JX-Tyg


Ena Valikov said...

Seralini:
 
As the total  chemical composition of the GM maize cannot be measured in details, the use of substantial equivalence is insufficient to highlight
potential unknown toxins and therefore cannot replace long-term
animal feeding trials for GMOs.
A cause of the effects of the effects could be that the NK603 GM maize used in this study is engineered to overexpress a modified version of the Agrobacterium tumefaciens 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) (Hammond et al., 2004) allowing the R tolerance. The modified EPSPS
is not inhibited by glyphosate by contrast to the wild enzyme. This
enzyme is known to drive the first step of aromatic amino acid biosynthesis in the plant shikimate pathway; in addition estrogenic
isoflavones and their glycosides are also products of this pathway
(Duke et al., 2003). They were not disturbed in our study. By contrast, the levels of caffeic and ferulic acids in the GM diets, which are also secondary metabolites from this pathway, but not always measured in regulatory tests, are significantly reduced. This may lower their protective effects against carcinogenesis and even
mammalian tumors (Kuenzig et al., 1984; Baskaran et al., 2010).
Moreover, these phenolic acids and in particular ferulic acid may
modulate estrogen receptors or the estrogenic pathway in mammalian cells (Chang et al., 2006). This does not exclude the action
of other unknown metabolites. This explanation also corresponds
to the fact that the observed effects of NK603 and R are not additive and reached a threshold. This implies that both the NK603
maize and R may cause hormonal disturbances in the same
biochemical and physiological pathway
 
 
One more thing. I  appreciate the offer you made to send me articles behind pay walls. I accessed the following two,
 
ferulic and caffeic acids, page 128-129
 
http://samples.jbpub.com/9780763764012/64012_Ch08_0148_rev.pdf
 
 
 
Antiproliferative and apoptotic effects of selective phenolic acids on T47D human breast cancer cells: potential mechanisms of action
Marilena Kampa,1 Vassilia-Ismini Alexaki,1 George Notas,2 Artemissia-Phoebe Nifli,1 Anastassia Nistikaki,1Anastassia Hatzoglou,1 Efstathia Bakogeorgou,1 Elena Kouimtzoglou,3 George Blekas,4 Dimitrios Boskou,4 Achille Gravanis,3 and Elias Castanas1
Author information ► Article notes ► Copyright and License information ►
This article has been cited by other articles in PMC.
Go to:
Abstract
Introduction
The oncoprotective role of food-derived polyphenol antioxidants has been described but the implicated mechanisms are not yet clear. In addition to polyphenols, phenolic acids, found at high concentrations in a number of plants, possess antioxidant action. The main phenolic acids found in foods are derivatives of 4-hydroxybenzoic acid and 4-hydroxycinnamic acid.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400651/

but would appreciate if you could send me the other articles I can’t access.
 

Thanks!
 
 

Ena Valikov said...

Articles I would like to read.

Chemopreventive potential of ferulic acid in 7,12-dimethylbenz[a]anthracene-induced mammary carcinogenesis in Sprague–Dawley rats
·         Nagarethinam Baskaran, 
·         Shanmugam Manoharan, , 
·         Subramanian Balakrishnan, 
·         Pachaiappan Pugalendhi
·         Department of Biochemistry & Biotechnology, Faculty of Science, Annamalai University, Annamalainagar – 608 002, Tamil Nadu, India
·         http://dx.doi.org/10.1016/j.ejphar.2010.03.054, How to Cite or Link Using DOI
·         Permissions & Reprints
 
 
2.  Lipophilic caffeic and ferulic acid derivatives presenting cytotoxicity against human breast cancercells.
Serafim TL, Carvalho FS, Marques MP, Calheiros R, Silva T, Garrido J, Milhazes N, Borges F, Roleira F, Silva ET, Holy J, Oliveira PJ.
Source

In the present work, lipophilic caffeic and ferulic acid derivatives were synthesized, and their cytotoxicity on cultured breast cancer cells was compared. A total of six compounds were initially evaluated: caffeic acid (CA), hexyl caffeate (HC), caffeoylhexylamide (HCA), ferulic acid (FA), hexyl ferulate (HF), and feruloylhexylamide (HFA). Cell proliferation, cell cycle progression, and apoptotic signaling were investigated in three human breast cancer cell lines, including estrogen-sensitive (MCF-7) and insensitive (MDA-MB-231 and HS578T). Furthermore, direct mitochondrial effects of parent and modified compounds were investigated by using isolated liver mitochondria. The results indicated that although the parent compounds presented no cytotoxicity, the new compounds inhibited cell proliferation and induced cell cycle alterations and cell death, with a predominant effect on MCF-7 cells. Interestingly, cell cycle data indicates that effects on nontumor BJ fibroblasts were predominantly cytostatic and not cytotoxic. The parent compounds and derivatives also promoted direct alterations on hepatic mitochondrial bioenergetics, although the most unexpected and never before reported one was that FA induces the mitochondrial permeability transition. The results show that the new caffeic and ferulic acid lipophilic derivatives show increased cytotoxicity toward human breast cancer cell lines, although the magnitude and type of effects appear to be dependent on the cell type. Mitochondrial data had no direct correspondence with effects on intact cells suggesting that this organelle may not be a critical component of the cellular effects observed. The data provide a rational approach to the design of effective cytotoxic lipophilic hydroxycinnamic derivatives that in the future could be profitably applied for chemopreventive and/or chemotherapeutic purposes.

 
 
3.  Impact of alkyl esters of caffeic and ferulic acids on tumor cell proliferation, cyclooxygenase enzyme, and lipid peroxidation.
Jayaprakasam B, Vanisree M, Zhang Y, Dewitt DL, Nair MG.
J Agric Food Chem. 2006 Jul 26;54(15):5375-81.
Source
Bioactive Natural Products and Phytoceuticals, Department of Horticulture and National Food Safety and Toxicology Center, Michigan State University, East Lansing, Michigan 48824, USA.
Abstract
The antioxidant ferulic and caffeic acid phenolics are ubiquitous in plants and abundant in fruits and vegetables. We have synthesized a series of ferulic and caffeic acid esters and tested for tumor cell proliferation, cyclooxygenase enzymes (COX-1 and -2) and lipid peroxidation inhibitory activities in vitro. In the tumor cell proliferation assay, some of these esters showed excellent growth inhibition of colon cancer cells.


Thanks a lot
 

Kevin M. Folta said...

Ena, No problem. I'm home now so I can't grab them tonight, but tomorrow. Can you send me an email address? Thanks. Mine is kevinfolta at gmail

Ena Valikov said...

Hi Kevin.



Thanks for those articles. After scanning them my gut feeling is that phenolics aren’t it. I can imagine high levels in foods Slowing down growth of neoplasia, but I can’t imagine abnormally low levels independently of other xenobiotics Causing it.



If Seralini is correct in his threshold hypothesis –it needs to be either endocrine or epigenetic. I found a journal article you might find interesting in that it explains pretty well why your argument on lack of dose response falls apart in endocrinology: “Large effects from small exposures: nonlinear response of estrogen mimickers”: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241550/pdf/ehp0111-000994.pdf

I just can’t shake TWO CP4 EPSPS supercharging metabolism of aromatics in NK603, one of which is a tad odd while turbo charged by the rice actin promoter.
The mechanism would seem to be either via CP4 EPSPS creating 1)a de-novo phytoestrogen not described in the literature so far, 2) or somehow catalyzing one of the steps leading to a more “virulent” estrogen (i.e. 4 hydroxyestradiol, 4-hydroxy catechol estrogen / estradiol quinones)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC23537/

Or 3) enhancement of aromatase or

4) microRNAs.

Ena Valikov said...

Speaking of miRNAs, are the actual Monsanto transgenes sequences and the flanking sequences published? Is it possible to run a bioinformatics search for inverted repeats that can form hairpin RNAs upon read-through transcription on the transgene, the flanking regions paying attention to the anomalies listed below?

A band of -0.2 kb was detected in the “short run” test DNA (lane 5) indicating the presence of an additional fragment containing sequence from the P-racti/ractl intron. The -0.2-kb band was not detected in lane 2 because it was not retained on the gel after the “long run”. Further experiments which determined the sequence of the ends of the integrated DNA in NK603 revealed that an additional 217-bp fragment containing a portion of the enhancer region of the rice actin promoter was present in the reverse orientation proximal to the 3’ end of the transformation cassette, and that this small fragment maintained an EcoRV site 20-bp upstream from its 3’ end bordering corn genomic sequence (Figure 12). These findings confirmed and explained the results from this Southern blot analysis.The 217-bp fragment includes polylinker sequence (50 bp) and the first 167 bp of the enhancer region of the rice actin promoter, position -835 to -669 from the start of transcription as defined by McElroy et al. (1990). Neither the TATA box nor transcriptional initiation site is present within the fragment, which suggests that this fragment should not function as a promoter.

Nucleotide sequencing indicated that the sequence of the CP4 EPSPS gene within the second (3’ proximal) cassette differed by two nucleotides from the inserted sequence. This gave rise to a single amino acid substitution at position 214 of the expressed protein (leucine --> proline; variant protein referred to as: CP4 EPSPS L214P).
Analyses of specific PCR products from the 3’ terminus of the inserted DNA revealed that an additional segment comprising 305 bp of chloroplast DNA had been co-integrated. Bioinformatics analysis indicated that this sequence corresponded to a portion of the maize DNA-directed RNA polymerase alpha-subunit and ribosomal S11 protein. The source of this DNA was believed to be the chloroplast of the transformed cell
http://www.cera-gmc.org/?action=gm_crop_database&mode=ShowProd&data=NK603

Almost forgot. Given that this is a rebuttal of criticism of Seralini, and I hate double standards and asymmetry, I thought it would be appropriate to post the Hammond mirror piece for your criticism.
Results of a 13 week safety assurance study with rats fed grain from glyphosate tolerant corn by Monsanto Company, 800 N. Lindbergh, St Louis, MO, 63167, USA by Hammond et al.
http://cera-gmc.org/docs/articles/09-215-016.pdf
I notice it is published in that same low level rag: Food and Chemical Toxicology 42 (2004) 1003–1014, just exactly the same as Seralini. Does that mean that this safety study is rubbish as well, Kevin?

Ena Valikov said...

{And the food you eat is not sterile. You consume bacterial and fungal RNA every day by the bucket and none of that has ever been tested.}
I know that. You should see the look on people's faces when I show them mites that live on their eyelashes.
Moreover, the miRNA content of the blood has been well characterized—literally hundreds of papers.

{In all of these surveys why are dietary/bacteria/fungal miRNAs not found? I dunno.}
I believe it is because we have pancreatic ribonucleases, but I am not convinced they evolve as quickly as biotechnology in a span of a few decades.
http://www.ncbi.nlm.nih.gov/pubmed/16950759

Tiffany Villegas said...

Hello Kevin,

I wanted to start out by saying thank you for having this blog where everyone has the chance to pose their questions and opinions.

Both Seralini and Manuela Malatesta's tests showed that GMO foods induced negative effects on their subjects.

If one truly felt that these studies were inaccurate there would have been additional tests run to disprove the original findings. That is the way "good" science works.

I don't see that any additional testing has been done. This leads me to believe whole heartedly that the reason this was not done is because the belief is that the replicated studies would draw the same conclusion.

I wanted to know what your thoughts and opinions were on this question.

Why haven't the Seralini and Manuela Malatesta's tests ever replicated?

Could it be that in doing so one might prove that this is harmful and could potential be the cause of chronic disease and shorten people’s life spans.

Thank you,

Tiffany

Kevin M. Folta said...

2-part answer, part 1
Tiffany, thanks for the note. I appreciate your well thought out questions. Here are my thoughts:

Both Seralini and Manuela Malatesta's tests showed that GMO foods induced negative effects on their subjects.

But Seralini's work really didn't show that GMO foods induced negative effects. The criticisms are accurate and consistently show the sloppy science behind the study. I won't go into here, it has been brilliantly debunked by VIB in Belgium.

Malatesta's work is a little different. I think the researchers are certainly competent in the techniques, at least I don't know enough about them to be critical. What I do remember about these studies is that the diets were not reported, just that it was GMO and non-GMO. That leaves a lot of wiggle room in the soybean world. The test should be the transgenic and isogenic line. Soy is loaded with isoflavones, phytoestrogens, etc and they vary highly from line to line. That could more plausibly underlie the physiology reported.

If one truly felt that these studies were inaccurate there would have been additional tests run to disprove the original findings. That is the way "good" science works.

I'll disagree there. Good science never sets out to prove or disprove something. That's why Seralni's work is so awful. Good science tests a hypothesis. When we compare the tests that say there are no harmful effects and those that do, the ones that show harm come from the same labs and play fast and loose with the treatments. That's important. When we consider all of the work together the best studies outweigh sporadic reports of harm.

Plus, I'm not sure if the reported differences in Malatesta are indicative of deleterious health or just differences in cellular morphology. I'll revisit this.

I don't see that any additional testing has been done. This leads me to believe whole heartedly that the reason this was not done is because the belief is that the replicated studies would draw the same conclusion.

I think you have it backwards. Replicated studies with statistically meaningful numbers likely showed no treatment effect and were not published. Remember, the scientist that shows definitive proof that 95% of USA acreage is poison will receive a Nobel Prize. I hope it's me!

If I wanted to do this study and wrote to NIH or NSF for funding they would never fund it. There's no plausible mechanism for harm beyond mundane explanations. It would never be replicated, because the primary findings are not trustworthy.

Kevin M. Folta said...

Two part answer, part 2

I wanted to know what your thoughts and opinions were on this question.

Why haven't the Seralini and Manuela Malatesta's tests ever replicated?

Could it be that in doing so one might prove that this is harmful and could potential be the cause of chronic disease and shorten people’s life spans.


Again, if it is real, it should be reproducible. Other labs, many others, should jump all over this to be the first to show that 95% of USA, Brazil and Argentina's acreage is toxic in a definitive, solid study. If these first papers held water you'd see a mad dash for more studies, bigger studies.

But real scientists look at this report and see no reason to follow up. It is scientifically DOA.

And there is a little double standard at play when the opponents of transgenic technology cry foul when an author on a paper has some ancient tenuous tie to Monsanto, yet Seralini's work is funded by an anti-GMO organization and he heads an institute designed to find fault with GMO, and he publishes opinion books about GMO harm.

Tiffany, you, me, Ena, and the rest are all on the same page. We want more safe food that is better for people and the environment. Biotech has its strengths and limits. However, we can't let sloppy science shape our decisions. If it is harmful, then that's fine, I'll freely admit it and endorse the work. However, it is going to take some good experiments with solid numbers to exceed the evidence threshold needed to be convincing. If it is real, then it would be do-able.

Ena Valikov said...

An article you might find interesting

A novel endocrine-disrupting agent in corn with mitogenic activity in human breast and prostatic cancer cells.
Barry Markaverich, Shaila Mani, Mary Ann Alejandro, Andrea Mitchell, David Markaverich, Trellis Brown, Claudia Velez-Trippe, Chris Murchison, Bert O'Malley, and Robert Faith
Author information ► Copyright and License information ►
See letter "Corn and corn-derived products: sources of endocrine disruptors." in volume 111 on page A691.
This article has been cited by other articles in PMC.
Abstract
Housing adult rats on ground corncob bedding impedes male and female mating behavior and causes acyclicity in females. The suppressive effects on ovarian cyclicity are mimicked by a mitogenic agent purified from the ground corncob bedding material (corn mitogen; CM), which stimulates the proliferation of estrogen receptor (ER)-positive (MCF-7 cells) and ER-negative (MDA-MD-231 cells) breast cancer cells. Purified CM does not compete for [(3)H]estradiol binding to ER or nuclear type II sites, and its effects on MCF-7 breast cancer cell proliferation are not blocked by the antiestrogen ICI-182,780. These results suggest that the active component is unlikely to be a phytoestrogen, bioflavonoid, mycotoxin, or other known endocrine-disrupting agent that modifies cell growth via ER or type II [(3)H]estradiol binding sites. CM also stimulates the proliferation of PC-3 human prostatic cancer cells in vitro, and the growth rate of PC-3 cell xenografts is accelerated in nude male mice housed on ground corncob as opposed to pure cellulose bedding. Consequently, this endocrine-disrupting agent in ground corncob bedding may influence behavioral and physiologic reproductive response profiles and malignant cell proliferation in experimental animals. Fresh corn (kernels and cob) or corn tortillas also contain CM, indicating that human exposure is likely; consequently, CM and/or related mitogens in corn products may influence human health and development.

Full Text
The Full Text of this article is available as a PDF (559K).

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1240732/

Cheers,
Ena

Kevin M. Folta said...

Didn't find it that remarkable. Seems like okay data and has its limitations for interpretation.

We've known for a long time that you don't house rodents on cedar chips or other wood that emits volatile hydrocarbons,etc. They don't say anything about the genotype of the corn or even who made it.

The Discussion suggests that corn itself may maintain CM as it is found in tortillas.

So based on these data from a limited study with some nice dose-response data from multiple models, to you recommend to not eat corn?

Ena Valikov said...

Given that the corn in the taco shells and the bedding was unlabeled, it is obviously impossible to tell which variety of corn;though it is likely it was transgenic. It seems a good idea to have the manufacturers of transgenic corn seeds analyze their variety for leukotoxin diols....

Leukotoxin diols from ground corncob bedding disrupt estrous cyclicity in rats and stimulate MCF-7 breast cancer cell proliferation.
Markaverich BM, Crowley JR, Alejandro MA, Shoulars K, Casajuna N, Mani S, Reyna A, Sharp J.
Source
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA. barrym@bcm.tmc.edu
Abstract
Previous studies in our laboratory demonstrated that high-performance liquid chromatography (HPLC) analysis of ground corncob bedding extracts characterized two components (peak I and peak II) that disrupted endocrine function in male and female rats and stimulated breast and prostate cancer cell proliferation in vitro and in vivo. The active substances in peak I were identified as an isomeric mixture of 9,12-oxy-10,13-dihydroxyoctadecanoic acid and 10,13-oxy-9,12-dihydroxyoctadecanoic acid, collectively designated tetrahydrofurandiols (THF-diols). Studies presented here describe the purification and identification of the HPLC peak II component as 9,10-dihydroxy-12-octadecenoic acid (leukotoxin diol; LTX-diol), a well-known leukotoxin. A synthetic mixture of LTX-diol and 12,13-dihydroxy-9-octadecenoic acid (iso-leukotoxin diol; i-LTX-diol) isomers was separated by HPLC, and each isomer stimulated (p < 0.001) MCF-7 cell proliferation in an equivalent fashion. The LTX-diol isomers failed to compete for [3H]estradiol binding to the estrogen receptor or nuclear type II sites, even though oral administration of very low doses of these compounds (>> 0.8 mg/kg body weight/day) disrupted estrous cyclicity in female rats. The LTX-diols did not disrupt male sexual behavior, suggesting that sex differences exist in response to these endocrine-disruptive agents. http://www.ncbi.nlm.nih.gov/pubmed/16330350

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DR IFADE SPECIALIZE IN ALL OF THIS SO I URGE YOU WITHOUT DELAY TO CONTACT HIM FOR HELP ;
Permanent penis enlargement
Thick penis
Bigger penis head
Effective erections
HIV
ALS
HERPES
CANCER
Best regard
BRIAN WALKER.

BRIANWALKER694 said...

Hello everyone am BRIAN WALKER,
From USA , i am here to give my testimony about a spell caster called DR IFADE, I was heartbroken because i had very small penis, not big enough to satisfy a woman, i have been in so many relationship, but cut off because of my situation, i have used so many product which doctors prescribe for me, but none could offer me the help i searched for. i saw some few comments on the internet about this specialist called Dr IFADE and decided to email him on his email i saw on the internet,(ifadesolutionspell31@gmail.com) so I decided to give his herbal product a try. i emailed him and he got back to me, he gave me some comforting words with his herbal pills for Penis Enlargement, Within 3 week of it, i began to feel the enlargement of my penis, ” and now it just 4 weeks of using his products my penis is about 9 inches longer, and i had to settle out with my Ex girlfriend Kate, i was surprised when she said that she is satisfied with my sex and i have got a large penis.
Am so happy, thanks to Dr IFADE. i urge you now to contact DR IFADE
for help on his email via (ifadesolutionspell31@gmail.com or call and whatsapp him on his mobile +2349060120490.

DR IFADE SPECIALIZE IN ALL OF THIS SO I URGE YOU WITHOUT DELAY TO CONTACT HIM FOR HELP ;
Permanent penis enlargement
Thick penis
Bigger penis head
Effective erections
HIV
ALS
HERPES
CANCER
Best regard
BRIAN WALKER.


Hello everyone am BRIAN WALKER,
From USA , i am here to give my testimony about a spell caster called DR IFADE, I was heartbroken because i had very small penis, not big enough to satisfy a woman, i have been in so many relationship, but cut off because of my situation, i have used so many product which doctors prescribe for me, but none could offer me the help i searched for. i saw some few comments on the internet about this specialist called Dr IFADE and decided to email him on his email i saw on the internet,(ifadesolutionspell31@gmail.com) so I decided to give his herbal product a try. i emailed him and he got back to me, he gave me some comforting words with his herbal pills for Penis Enlargement, Within 3 week of it, i began to feel the enlargement of my penis, ” and now it just 4 weeks of using his products my penis is about 9 inches longer, and i had to settle out with my Ex girlfriend Kate, i was surprised when she said that she is satisfied with my sex and i have got a large penis.
Am so happy, thanks to Dr IFADE. i urge you now to contact DR IFADE
for help on his email via (ifadesolutionspell31@gmail.com or call and whatsapp him on his mobile +2349060120490.

DR IFADE SPECIALIZE IN ALL OF THIS SO I URGE YOU WITHOUT DELAY TO CONTACT HIM FOR HELP ;
Permanent penis enlargement
Thick penis
Bigger penis head
Effective erections
HIV
ALS
HERPES
CANCER
Best regard
BRIAN WALKER.

BRIANWALKER694 said...

Hello everyone am BRIAN WALKER,
From USA , i am here to give my testimony about a spell caster called DR IFADE, I was heartbroken because i had very small penis, not big enough to satisfy a woman, i have been in so many relationship, but cut off because of my situation, i have used so many product which doctors prescribe for me, but none could offer me the help i searched for. i saw some few comments on the internet about this specialist called Dr IFADE and decided to email him on his email i saw on the internet,(ifadesolutionspell31@gmail.com) so I decided to give his herbal product a try. i emailed him and he got back to me, he gave me some comforting words with his herbal pills for Penis Enlargement, Within 3 week of it, i began to feel the enlargement of my penis, ” and now it just 4 weeks of using his products my penis is about 9 inches longer, and i had to settle out with my Ex girlfriend Kate, i was surprised when she said that she is satisfied with my sex and i have got a large penis.
Am so happy, thanks to Dr IFADE. i urge you now to contact DR IFADE
for help on his email via (ifadesolutionspell31@gmail.com or call and whatsapp him on his mobile +2349060120490.

DR IFADE SPECIALIZE IN ALL OF THIS SO I URGE YOU WITHOUT DELAY TO CONTACT HIM FOR HELP ;
Permanent penis enlargement
Thick penis
Bigger penis head
Effective erections
HIV
ALS
HERPES
CANCER
Best regard
BRIAN WALKER.


Hello everyone am BRIAN WALKER,
From USA , i am here to give my testimony about a spell caster called DR IFADE, I was heartbroken because i had very small penis, not big enough to satisfy a woman, i have been in so many relationship, but cut off because of my situation, i have used so many product which doctors prescribe for me, but none could offer me the help i searched for. i saw some few comments on the internet about this specialist called Dr IFADE and decided to email him on his email i saw on the internet,(ifadesolutionspell31@gmail.com) so I decided to give his herbal product a try. i emailed him and he got back to me, he gave me some comforting words with his herbal pills for Penis Enlargement, Within 3 week of it, i began to feel the enlargement of my penis, ” and now it just 4 weeks of using his products my penis is about 9 inches longer, and i had to settle out with my Ex girlfriend Kate, i was surprised when she said that she is satisfied with my sex and i have got a large penis.
Am so happy, thanks to Dr IFADE. i urge you now to contact DR IFADE
for help on his email via (ifadesolutionspell31@gmail.com or call and whatsapp him on his mobile +2349060120490.

DR IFADE SPECIALIZE IN ALL OF THIS SO I URGE YOU WITHOUT DELAY TO CONTACT HIM FOR HELP ;
Permanent penis enlargement
Thick penis
Bigger penis head
Effective erections
HIV
ALS
HERPES
CANCER
Best regard
BRIAN WALKER.

BRIANWALKER694 said...

Hello everyone am BRIAN WALKER,
From USA , i am here to give my testimony about a spell caster called DR IFADE, I was heartbroken because i had very small penis, not big enough to satisfy a woman, i have been in so many relationship, but cut off because of my situation, i have used so many product which doctors prescribe for me, but none could offer me the help i searched for. i saw some few comments on the internet about this specialist called Dr IFADE and decided to email him on his email i saw on the internet,(ifadesolutionspell31@gmail.com) so I decided to give his herbal product a try. i emailed him and he got back to me, he gave me some comforting words with his herbal pills for Penis Enlargement, Within 3 week of it, i began to feel the enlargement of my penis, ” and now it just 4 weeks of using his products my penis is about 9 inches longer, and i had to settle out with my Ex girlfriend Kate, i was surprised when she said that she is satisfied with my sex and i have got a large penis.
Am so happy, thanks to Dr IFADE. i urge you now to contact DR IFADE
for help on his email via (ifadesolutionspell31@gmail.com or call and whatsapp him on his mobile +2349060120490.

DR IFADE SPECIALIZE IN ALL OF THIS SO I URGE YOU WITHOUT DELAY TO CONTACT HIM FOR HELP ;
Permanent penis enlargement
Thick penis
Bigger penis head
Effective erections
HIV
ALS
HERPES
CANCER
Best regard
BRIAN WALKER.


Hello everyone am BRIAN WALKER,
From USA , i am here to give my testimony about a spell caster called DR IFADE, I was heartbroken because i had very small penis, not big enough to satisfy a woman, i have been in so many relationship, but cut off because of my situation, i have used so many product which doctors prescribe for me, but none could offer me the help i searched for. i saw some few comments on the internet about this specialist called Dr IFADE and decided to email him on his email i saw on the internet,(ifadesolutionspell31@gmail.com) so I decided to give his herbal product a try. i emailed him and he got back to me, he gave me some comforting words with his herbal pills for Penis Enlargement, Within 3 week of it, i began to feel the enlargement of my penis, ” and now it just 4 weeks of using his products my penis is about 9 inches longer, and i had to settle out with my Ex girlfriend Kate, i was surprised when she said that she is satisfied with my sex and i have got a large penis.
Am so happy, thanks to Dr IFADE. i urge you now to contact DR IFADE
for help on his email via (ifadesolutionspell31@gmail.com or call and whatsapp him on his mobile +2349060120490.

DR IFADE SPECIALIZE IN ALL OF THIS SO I URGE YOU WITHOUT DELAY TO CONTACT HIM FOR HELP ;
Permanent penis enlargement
Thick penis
Bigger penis head
Effective erections
HIV
ALS
HERPES
CANCER
Best regard
BRIAN WALKER.

BRIANWALKER694 said...

Hello everyone am BRIAN WALKER,
From USA , i am here to give my testimony about a spell caster called DR IFADE, I was heartbroken because i had very small penis, not big enough to satisfy a woman, i have been in so many relationship, but cut off because of my situation, i have used so many product which doctors prescribe for me, but none could offer me the help i searched for. i saw some few comments on the internet about this specialist called Dr IFADE and decided to email him on his email i saw on the internet,(ifadesolutionspell31@gmail.com) so I decided to give his herbal product a try. i emailed him and he got back to me, he gave me some comforting words with his herbal pills for Penis Enlargement, Within 3 week of it, i began to feel the enlargement of my penis, ” and now it just 4 weeks of using his products my penis is about 9 inches longer, and i had to settle out with my Ex girlfriend Kate, i was surprised when she said that she is satisfied with my sex and i have got a large penis.
Am so happy, thanks to Dr IFADE. i urge you now to contact DR IFADE
for help on his email via (ifadesolutionspell31@gmail.com or call and whatsapp him on his mobile +2349060120490.

DR IFADE SPECIALIZE IN ALL OF THIS SO I URGE YOU WITHOUT DELAY TO CONTACT HIM FOR HELP ;
Permanent penis enlargement
Thick penis
Bigger penis head
Effective erections
HIV
ALS
HERPES
CANCER
Best regard
BRIAN WALKER.


Hello everyone am BRIAN WALKER,
From USA , i am here to give my testimony about a spell caster called DR IFADE, I was heartbroken because i had very small penis, not big enough to satisfy a woman, i have been in so many relationship, but cut off because of my situation, i have used so many product which doctors prescribe for me, but none could offer me the help i searched for. i saw some few comments on the internet about this specialist called Dr IFADE and decided to email him on his email i saw on the internet,(ifadesolutionspell31@gmail.com) so I decided to give his herbal product a try. i emailed him and he got back to me, he gave me some comforting words with his herbal pills for Penis Enlargement, Within 3 week of it, i began to feel the enlargement of my penis, ” and now it just 4 weeks of using his products my penis is about 9 inches longer, and i had to settle out with my Ex girlfriend Kate, i was surprised when she said that she is satisfied with my sex and i have got a large penis.
Am so happy, thanks to Dr IFADE. i urge you now to contact DR IFADE
for help on his email via (ifadesolutionspell31@gmail.com or call and whatsapp him on his mobile +2349060120490.

DR IFADE SPECIALIZE IN ALL OF THIS SO I URGE YOU WITHOUT DELAY TO CONTACT HIM FOR HELP ;
Permanent penis enlargement
Thick penis
Bigger penis head
Effective erections
HIV
ALS
HERPES
CANCER
Best regard
BRIAN WALKER.

IVANOVIC SESSEW said...

After taking A.V.R.S for two weeks, i went back for a test and i never believed it became negative. it was like a miracle, because it all happened beyond my imagination. i was on line on a forum like this on face book, and i saw a post of a young lady whom gave her testimony on how she was cured from HIV by a HERBAL DOCTOR. DR. ATEKHA, i read it through and i decided to contact the doctor. i send him a mail and i got a reply in a short time, i was diagnosed and given advice on how to go about it. then i was also sent the A.V.R.S that was prepared by DR ATEKHA, that was the end of my sorrow.... he replied my mail and Needed some Information about me, then I sent them to him, he prepared it (CURE) and sent it to FEDex On line Courier Service for delivery, he gave my details to the Courier Office, they told me that 3-5 days I will receive the package and i took the AVRS medicine as prescribed by him and I went for check-up 2 weeks after finishing the medicine, I was tested HIV negative,if you have HIV and you have been looking for a cure, this is your best chance now, do not miss it, when you contact him,.(DR ATEKHA )make sure you tell him that I referenced you.. contact him via email: DRATEKHA99@GMAIL.COM ,phone number: +2348139747402

Clara walter said...

i am really happy that i have been cured from (HERPES SIMPLEX VIRUS) with
the herbal medicine of Dr Oduwa, i have been suffering from this disease
for the past 2 years and 7 mouth without solution until i came across the
email of this doctor who have cure so many people with his herbal medicine,
i also choose to give him a chance to help me and my husband, he told me
what to do and i kindly did it, and he gave us his herbal medicine and
direct me on how to use it, i also follow his instructions for use and he
ask us to go for a check up after 1 week and 4days which i did, to my
greatest surprise our result came out as negative, we are really happy that
there is someone like this doctor who is ready to help anytime any day. To
all the readers and viewers that is doubting this testimony should stop doubting
it and contact this doctor if you really have one and see if he will not
actually help you. i am not a stupid woman that i will come out to the
public and start saying what someone have not done for me and i know that
there are some people out there who are really suffering and hurting their
family just because of these diseases so you can email him on
(droduwaspellhome01@gmail.com)
or you can also whatsapp him on +2348136354191
he also told me that he has cure all these diseases listed below
. HERPES SIMPLEX VIRUS.
.ALS
. CANCER
.HEPATITIS
.HIV/AIDS
HSV
Thank you for your time bye

Lisa Caillo said...

What a miracle i never believe there is cure because my doctor tested me Herpes positive and she told me there is no cure, i’m very happy today that i’m having a free life without this sickness, i can remember some months ago when i was crying all through the night and day that i can’t get cured from this sickness, i found this herbal man email on internet when i was doing research on cure for Herpes i contacted him to found out if i can get help from this sickness, i was so surprise when he told me that he have the herbs cure to it and he sent me the herbal in less down 2-3 days i was so happy when i get someone giving me hope that he can cured me i took the herbal for just 2 weeks, when i went for test after taking the herbal i found out that i am cured i was so happy and surprise, i want to use this opportunity to inform you that there is cured to Herpes you can also contact him for his help as soon as possible so that you can get rid of this sickness once and for all you can reach him through via email: Chiefdrlucky@gmail.com or
Whats App him on +2348132777335
Website : http://chiefdrluckysolutionhome.website2.me/
You can also contact him on any sickness in this he all have the herbal cure to it

Willson Care said...

I am one of those people who said, “I’ll never call a psychic or a magician or whatever” to help me with my problems – least of all my love problems, but I reached the point where I knew I needed some guidance, and I’m so glad I found this man called dr.ajeghe. When I nearly lost David in one of our stupid,fights (he broke up with me), I thought I had lost everything.i cry all day and think that he will never come back to me again.i read so many testimony about Dr. ajeghe love spell,how he help to bring back ex lover back.I quickly email him.and also get back my husband with his love spell. And when I was at my most desperate,he didn’t take advantage of me. You performed a very good service for a person in true need. I don’t know how you did it, or how this magic works, but all I know is, IT WORKS!! David my husband and I are happily back together, and I’ll always be grateful to dr.ajeghe email him for any kinds of help is very capable and reliable for help ajeghespelltemple@gmail.com or WhatsApp him +2349069171173

David Richardson said...

HOW DR PERFECT ENLARGEMENT CREAM HELP ME TO ENLARGE MY PENIS YOU CAN ADD HIM UP ON WHATSAPP +1(256) 251 3614

My name is David Richardson from USA I want to share a testimony of how Dr Perfect herbal mixture cream saved me from shame and disgrace, my penis was a big problem to me as the size was really so embarrassing and I was also having weak erection problem. I can't make love to my wife and my penis was just too small, a full grown man like me having 3 inches penis and to worsen it I don't last long in sex I can't even last four minutes it was really a big shame to me. My wife was really tired of me because my sex life was very poor, she never enjoyed sex, I was always thinking and searching for solutions everywhere until when I saw a testimony of how Dr Perfect herbal mixture cream have been helping people regarding their sex life, so I decided to give him a try and to my greatest surprise in less than one week of taking the herbs my penis grow to 10 inches I couldn't believe my eyes and as I speak now my penis is now 10 inches long and I don't have weak erection anymore. I can make love to my wife longer in bed. And my marriage is now stable my wife is now enjoy me very well in bed. All thanks to Dr Perfect for enlarging my penis he indeed save my marriage. You can contact him at solutiontoallproblems1@gmail.com or you can add him up on WhatsApp +1(256) 251 3614. He also specializes in the following things
Herpes virus
Cancer
Hsv
Chronic venous disease
and others

David Richardson said...

HOW DR PERFECT ENLARGEMENT CREAM HELP ME TO ENLARGE MY PENIS YOU CAN ADD HIM UP ON WHATSAPP +1(256) 251 3614

My name is David Richardson from USA I want to share a testimony of how Dr Perfect herbal mixture cream saved me from shame and disgrace, my penis was a big problem to me as the size was really so embarrassing and I was also having weak erection problem. I can't make love to my wife and my penis was just too small, a full grown man like me having 3 inches penis and to worsen it I don't last long in sex I can't even last four minutes it was really a big shame to me. My wife was really tired of me because my sex life was very poor, she never enjoyed sex, I was always thinking and searching for solutions everywhere until when I saw a testimony of how Dr Perfect herbal mixture cream have been helping people regarding their sex life, so I decided to give him a try and to my greatest surprise in less than one week of taking the herbs my penis grow to 10 inches I couldn't believe my eyes and as I speak now my penis is now 10 inches long and I don't have weak erection anymore. I can make love to my wife longer in bed. And my marriage is now stable my wife is now enjoy me very well in bed. All thanks to Dr Perfect for enlarging my penis he indeed save my marriage. You can contact him at solutiontoallproblems1@gmail.com or you can add him up on WhatsApp +1(256) 251 3614. He also specializes in the following things
Herpes virus
Cancer
Hsv
Chronic venous disease
and others

David Richardson said...

HOW DR PERFECT ENLARGEMENT CREAM HELP ME TO ENLARGE MY PENIS YOU CAN ADD HIM UP ON WHATSAPP +1(256) 251 3614

My name is David Richardson from USA I want to share a testimony of how Dr Perfect herbal mixture cream saved me from shame and disgrace, my penis was a big problem to me as the size was really so embarrassing and I was also having weak erection problem. I can't make love to my wife and my penis was just too small, a full grown man like me having 3 inches penis and to worsen it I don't last long in sex I can't even last four minutes it was really a big shame to me. My wife was really tired of me because my sex life was very poor, she never enjoyed sex, I was always thinking and searching for solutions everywhere until when I saw a testimony of how Dr Perfect herbal mixture cream have been helping people regarding their sex life, so I decided to give him a try and to my greatest surprise in less than one week of taking the herbs my penis grow to 10 inches I couldn't believe my eyes and as I speak now my penis is now 10 inches long and I don't have weak erection anymore. I can make love to my wife longer in bed. And my marriage is now stable my wife is now enjoy me very well in bed. All thanks to Dr Perfect for enlarging my penis he indeed save my marriage. You can contact him at solutiontoallproblems1@gmail.com or you can add him up on WhatsApp +1(256) 251 3614. He also specializes in the following things
Herpes virus
Cancer
Hsv
Chronic venous disease
and others

David Richardson said...

HOW DR PERFECT ENLARGEMENT CREAM HELP ME TO ENLARGE MY PENIS YOU CAN ADD HIM UP ON WHATSAPP +1(256) 251 3614

My name is David Richardson from USA I want to share a testimony of how Dr Perfect herbal mixture cream saved me from shame and disgrace, my penis was a big problem to me as the size was really so embarrassing and I was also having weak erection problem. I can't make love to my wife and my penis was just too small, a full grown man like me having 3 inches penis and to worsen it I don't last long in sex I can't even last four minutes it was really a big shame to me. My wife was really tired of me because my sex life was very poor, she never enjoyed sex, I was always thinking and searching for solutions everywhere until when I saw a testimony of how Dr Perfect herbal mixture cream have been helping people regarding their sex life, so I decided to give him a try and to my greatest surprise in less than one week of taking the herbs my penis grow to 10 inches I couldn't believe my eyes and as I speak now my penis is now 10 inches long and I don't have weak erection anymore. I can make love to my wife longer in bed. And my marriage is now stable my wife is now enjoy me very well in bed. All thanks to Dr Perfect for enlarging my penis he indeed save my marriage. You can contact him at solutiontoallproblems1@gmail.com or you can add him up on WhatsApp +1(256) 251 3614. He also specializes in the following things
Herpes virus
Cancer
Hsv
Chronic venous disease
and others

Mr Peter said...

Are you a business man/woman or an ARTISTS,POLITICIANS,PASTOR,ENGINEER,DOCTOR, STUDENTS, GRADUATED and you want to become Rich Powerful and famous, in life or,Are you frustrated in life. What type of wealth do you want? Today is your luckiest day, 'I want to join great Illuminati occult in Nigeria' we are here for those of you that want to join Illuminati Brotherhood in Nigeria and across Africa.Are you tired of poverty and now you want fame,power and riches Making wealth is guaranteed for the people of the world. Our magical powers are beyond your imagination. we could do magic on your behalf regarding , your financial situation, future events, or whatever is important to you. we have the power and we use the power.Life is a game. Money is how we keep scores. Money speaks sense in a language all nations understand. If you would know the value of money, go and try to borrow some; for he that goes borrowing goes sorrowing. We are a group of strong brothers who came from different walks of life for the purpose of alleviating the sufferings of our people we are Illuminati, and we could change the course of destiny Illuminati Brotherhood are most probably the most well known secret society in the world. Illuminati Brotherhood is not for Everyone, Is it someone or something you desire to have? Do you want wealth(Want to grow your bank account?, Need funds to enjoy the good life? Tired of working hard and getting nowhere?) or happiness? the most powerful society welcomes you to Illuminati..But we might be Right for you! We are Seeking our Dark Brothers and Sisters who have heard the call to come Home to the Illuminati Family! For those fortunate applicants of interest whom will be chosen to join the succeeding family of Illuminati, you will learn the untold secrets that few have ever known existed! The Illuminati rituals for securing Wealth, Health, Love, Lust and Power that none outside of this family have ever been taught and never will. . . we are here to protect you if you so desire! .. contact Illuminati initiation home Send us your most important desire and we shall work our powers in your favor. Be sure to tell Illuminati what you want. Email us now illuminatiwealth6666@gmail.com or call the agent now +2349030803982 you can e-mail to illuminatiwealth6666@gmail.com for immediately initiation.New members registration is now open online or call them on this number +2349030803982 our source of wealth and power is reviled to registered member only.Good LUCKY

mark alhsy said...

I will like to share this great testimony of buba.herbalmiraclemedicine@gmail.com or website https://bubaherbalmiraclemedicine.wordpress.com/ that helped me to save my marriage by increasing my Penis size and i now know that penis size really matters in a relationship or marriage. I got married to my wife about 2 month after we met on a photo studio, we lived happily for the first 5 months of our marriage until i and my wife start having quarrels at home because i couldn't satisfy her on bed with my small penis. Actually my penis was very small, it measured about 3.5 inch long on erection and i am 35 years old ,man. My wife said it was forbidden by the women of this world.. Sometimes i will return from work without finding my wife at home and whenever i call or ask her where she was, she will always snub at me and sometimes just tell me to go get a larger dick. All this continued for a long time and it hurt me so much that i was at the edge of breaking up on the marriage till when i read about a Herbal doctor called DR. MOSES BUBA online. I never thought i could smile and be in a happy marriage again if not for the help of DR MOSES BUBA I got the DR MOSES BUBA on his Emails: buba.herbalmiraclemedicine@gmail.com on the internet and i emailed him, and he got back to me with some encouraging words, he got me some herbal cream which i use for just 7 days and i began to feel the enlargement of my penis, and without surgery. This went on for a little period of about 10 days and to my greatest surprise my wife keeps screaming that she love my big dick now. Now my wife no longer fight with me, and my penis is now about 11.5 inches long on erection and off course very large round. And now my wife uses breasts, hips and bums enlargement. I and my wife are very happy for the help rendered to me by DR.MOSES BUBA, and i want to say a big thanks to DR MOSES BUBA for the help. You can contact DR MOSES BUBA on his Email: buba.herbalmiraclemedicine@gmail.com or visit his website https://bubaherbalmiraclemedicine.wordpress.com/
i am so thankful to DR MOSES BUBA for helping me. you can call OR whatsapp him +2349060529305

mark alhsy said...

I will like to share this great testimony of buba.herbalmiraclemedicine@gmail.com or website https://bubaherbalmiraclemedicine.wordpress.com/ that helped me to save my marriage by increasing my Penis size and i now know that penis size really matters in a relationship or marriage. I got married to my wife about 2 month after we met on a photo studio, we lived happily for the first 5 months of our marriage until i and my wife start having quarrels at home because i couldn't satisfy her on bed with my small penis. Actually my penis was very small, it measured about 3.5 inch long on erection and i am 35 years old ,man. My wife said it was forbidden by the women of this world.. Sometimes i will return from work without finding my wife at home and whenever i call or ask her where she was, she will always snub at me and sometimes just tell me to go get a larger dick. All this continued for a long time and it hurt me so much that i was at the edge of breaking up on the marriage till when i read about a Herbal doctor called DR. MOSES BUBA online. I never thought i could smile and be in a happy marriage again if not for the help of DR MOSES BUBA I got the DR MOSES BUBA on his Emails: buba.herbalmiraclemedicine@gmail.com on the internet and i emailed him, and he got back to me with some encouraging words, he got me some herbal cream which i use for just 7 days and i began to feel the enlargement of my penis, and without surgery. This went on for a little period of about 10 days and to my greatest surprise my wife keeps screaming that she love my big dick now. Now my wife no longer fight with me, and my penis is now about 11.5 inches long on erection and off course very large round. And now my wife uses breasts, hips and bums enlargement. I and my wife are very happy for the help rendered to me by DR.MOSES BUBA, and i want to say a big thanks to DR MOSES BUBA for the help. You can contact DR MOSES BUBA on his Email: buba.herbalmiraclemedicine@gmail.com or visit his website https://bubaherbalmiraclemedicine.wordpress.com/
i am so thankful to DR MOSES BUBA for helping me. you can call OR whatsapp him +2349060529305 .......

TORRES MADONA said...

my name is Promise dickson Finch am from Texas USA. I want to share a testimony of how Dr. OLU herbal mixture cream saves me from shame and disgrace, my penis was a big problem to me as the size was really so embarrassing,and i was also having weak erection problem. I can make love to my wife and my penis was just too small a full grown man like me having 4 inches penis and to worsen it i don't last in sex i cant even last two minutes it was really a thing of shame to me. My wife was really tired of me because my sex life was very poor,she never enjoyed sex,i was always thinking and searching for solutions everywhere until when i saw a testimony of how Dr. OLU. herbal mixture cream have been helping people regarding their sex life, so i decided to give him a try and to my greatest surprise in less than two weeks of taking the herbs my penis grow to 8 inches i couldn't believe my eyes and as i speak now my penis is now 8 inches and i do not have weak erection again. I can make love to my wife longer in bed. And my marriage is now stable,my wife now enjoy me very well in bed. You can contact him via (drolusolutionhome@gmail.com) You can contact him today and get your problem solved.Call +2348140654426 .." or you can also contact him through his what-app +238140654426




my name is Promise dickson Finch am from Texas USA. I want to share a testimony of how Dr. OLU herbal mixture cream saves me from shame and disgrace, my penis was a big problem to me as the size was really so embarrassing,and i was also having weak erection problem. I can make love to my wife and my penis was just too small a full grown man like me having 4 inches penis and to worsen it i don't last in sex i cant even last two minutes it was really a thing of shame to me. My wife was really tired of me because my sex life was very poor,she never enjoyed sex,i was always thinking and searching for solutions everywhere until when i saw a testimony of how Dr. OLU. herbal mixture cream have been helping people regarding their sex life, so i decided to give him a try and to my greatest surprise in less than two weeks of taking the herbs my penis grow to 8 inches i couldn't believe my eyes and as i speak now my penis is now 8 inches and i do not have weak erection again. I can make love to my wife longer in bed. And my marriage is now stable,my wife now enjoy me very well in bed. You can contact him via (drolusolutionhome@gmail.com) You can contact him today and get your problem solved.Call +2348140654426 .." or you can also contact him through his what-app +238140654426




Rose Sharon said...

Having herpes is not the end of life there many treatment to cure herpes infection with the help of Dr Edidia herbal product.
I was positive to the deadly virus called HERPES and i lost hope because i
was out casted and rejected even by my closet friends.
i searched on-line to know and enquirer about cure for HERPES and i read
someone testimony on how he was cured from HSV-2 so i decided to contact
the same herbalist Call Dr Edidia because i know that nature has the power
to heal everything.
i contacted him to know how he can help me and he told me never to worry
that he will help me with the natural herbs from God!
after 2 days of contacting him, he told me that the cure has been ready and
he sent it to me via UPS SPEED POST and it got to me after 3 days!
i used the medicine as he instructed me (MORNING and EVENING) and i was
cured!
its really like a dream but i am so happy!
thats the reason i decided to also add more comment of Him so that more can
be saved just like me!
and if you need his help, you can email him on dredidiaherbalhome@gmail.com
or whatsapp +2349074505296
here is the Dr website http://dredidiaherbalhome.weebly.com/

I,m rosesharon and you can get intouch with me via rosesharon915@gmail.com also view website to know him



Lisa Caillo said...

I want to use this medium to testify of how i got back my ex husband after divorce, i and my husband have been married for 8 years with 2 kids, we have been a happy family. Last year his behavior towards me and the kids changed, i suspected he was meeting another woman outside out marriage, any time i confronted him, he threatened to divorce me, i did all i could to make hings right but all to no avail until i saw a post on a "love and relationship forum" about a spell caster who helps people to cast spell on marriage and relationship issues, when i contacted this spell caster via email, he helped me cast a re-union spell and my husband changed and came apologizing to me and the kids. Contact this great spell caster for your relationship or marriage issues via this email: chiefdrlucky@gmail.com or Whats App him on +2348132777335 Website: http://chiefdrluckysolutionhome.website2.me/ Good luck

alisha gree said...

I am Miss alisha,From USA. I will start by saying to all that have experience heart break and also cant do with out there lover should please stop here and read up my story, So as you will know how to go solving or getting your ex back from this spell caster..AND AGAIN I WILL WANT TO ALSO TELL ALL THAT THIS SPELL CASTER I WILL WANT TO TELL THE WHOLE WORLD ABOUT IS HARMLESS AND DO NOT HAVE ANY SIDE EFFECT, BUT TO RESTORE AND GIVE YOU BACK WHAT YOU DESERVE, COS WHEN I MEET WITH THIS SPELL CASTER THAT WAS INTRODUCED TO ME BY THE WIFE OF MY BOSS IN MY WORKING PLACE, HE MADE IT CLEAR THAT HE CAN CAST SPELL ON SO MANY OTHER PROBLEMS EXCEPT IN GETTING YOUR EX OR MAKING YOUR LOVER TO LOVE YOU MORE THAT WILL SUITE YOU. Last year December, My lover was cheating on me and was not also give me the attention that a man should give to a woman,And really that was troubling my mind and tearing my heart apart to the extent that i was not concentrating in the office the way i use to before the break up by my lover.And before that incident,I always see how my boss use to love his wife so much. I was bringing to think that i was not doing the right thing to him that will make him love me forever,So i really gathered my courage and went to my boss wife office to ask her the secret that made her husband love her so dearly,In the first place she refused in telling me,She asked me why i am asking her such a question,That if is it not normal for every man to love his wife.I told her the reason that made me ask her about this question,That my lover started cheating on me lately,When i knelt down before her for her to see my seriousness in this issue that i went to ask her,She opened up to me by telling me that i should not tell anybody about what she want to tell me,The wife to my boss started to say to me that she used a very powerful spell on his husband to love her,And the spell that she used is harmless, But the spell is just to make him love her and never to look for any other woman except her. I QUICKLY ASK HER HOW DID SHE GET TO KNOW THIS GREAT,POWER,DURABLE AND PERFECT WORK SPELL CASTER,she said that a friend of hers also introduce her to him. Then i also ask her how i can meet with this spell caster.SHE SAID EVERYTHING TO ME,THAT THE NAME OF THIS SPELL CASTER IS Dr.AZEN .My next question to her was how can i get this wonderful spell caster,She said she is going to give me the email of the spell caster for me to contact him for my problem,Really she gave to me this spell caster email:[azentemple@gmail.com]or what'sapp +2349038299828. and i contacted him and explained all to him,And after every thing that needed to be done by the spell caster, In the next two days, My lover that hated me so much came to house begging for forgiveness and i was so glad that i have finally gotten my heart desire..I was so grateful to this spell caster for what he has done for my life.. So i made a promise to him that i will always come

alisha gree said...

I am Miss alisha,From USA. I will start by saying to all that have experience heart break and also cant do with out there lover should please stop here and read up my story, So as you will know how to go solving or getting your ex back from this spell caster..AND AGAIN I WILL WANT TO ALSO TELL ALL THAT THIS SPELL CASTER I WILL WANT TO TELL THE WHOLE WORLD ABOUT IS HARMLESS AND DO NOT HAVE ANY SIDE EFFECT, BUT TO RESTORE AND GIVE YOU BACK WHAT YOU DESERVE, COS WHEN I MEET WITH THIS SPELL CASTER THAT WAS INTRODUCED TO ME BY THE WIFE OF MY BOSS IN MY WORKING PLACE, HE MADE IT CLEAR THAT HE CAN CAST SPELL ON SO MANY OTHER PROBLEMS EXCEPT IN GETTING YOUR EX OR MAKING YOUR LOVER TO LOVE YOU MORE THAT WILL SUITE YOU. Last year December, My lover was cheating on me and was not also give me the attention that a man should give to a woman,And really that was troubling my mind and tearing my heart apart to the extent that i was not concentrating in the office the way i use to before the break up by my lover.And before that incident,I always see how my boss use to love his wife so much. I was bringing to think that i was not doing the right thing to him that will make him love me forever,So i really gathered my courage and went to my boss wife office to ask her the secret that made her husband love her so dearly,In the first place she refused in telling me,She asked me why i am asking her such a question,That if is it not normal for every man to love his wife.I told her the reason that made me ask her about this question,That my lover started cheating on me lately,When i knelt down before her for her to see my seriousness in this issue that i went to ask her,She opened up to me by telling me that i should not tell anybody about what she want to tell me,The wife to my boss started to say to me that she used a very powerful spell on his husband to love her,And the spell that she used is harmless, But the spell is just to make him love her and never to look for any other woman except her. I QUICKLY ASK HER HOW DID SHE GET TO KNOW THIS GREAT,POWER,DURABLE AND PERFECT WORK SPELL CASTER,she said that a friend of hers also introduce her to him. Then i also ask her how i can meet with this spell caster.SHE SAID EVERYTHING TO ME,THAT THE NAME OF THIS SPELL CASTER IS Dr.AZEN .My next question to her was how can i get this wonderful spell caster,She said she is going to give me the email of the spell caster for me to contact him for my problem,Really she gave to me this spell caster email:[azentemple@gmail.com]or what'sapp +2349038299828. and i contacted him and explained all to him,And after every thing that needed to be done by the spell caster, In the next two days, My lover that hated me so much came to house begging for forgiveness and i was so glad that i have finally gotten my heart desire..I was so grateful to this spell caster for what he has done for my life.. So i made a promise to him that i will always come

How doctor olu help me to increase my penis size said...

Hello everyone, am very happy to share this little awesome testimony about Dr olu a great herbal doctor who help me enlarge my penis size.3.2 cm to 8.3 cm longer with his herbal cream mixture, my girlfriend is now so amazed with the autonomous size of my penis , if you you are also in need of help on how to enlarge your penis to become bigger and stronger I adverse you to contact Dr on his email (drolusolutionhome@gmail.com) ) you or contact on whatsapp number +2348140654426 because he is one of the best herbal doctor that i can only show you up to, if your penis is 4.2 cm and want to get it reach 9.2 cm within three weeks i Dr olu is also specialized on obey m breast and boobs enlargement i advise you to contact him for help

alisha gree said...

I was diagnose of Chronic Obstructive Pulmonary Disease (COPD) 2 years ago, my family doctor told me there is no cure but it can only be controled. Ever since then i have been running heather scepter looking for a solution to my problem because i was going to lose my Job if i dont get better, until i ran into this online testimony of Mrs Alicia who have been cured of COPD by this herbal clinic in Africa (Astoria Herbal Clinic), i immediately contacted them via their email (azentemple@gmailcom), to God be thy glory i bought this COPD herbal remedy and was cured within 3 weeks of usage, at last this is a break through for all COPD patients contact this herbal clinic via their email ( azentemple@gmailcom) or whasapp +2349038299828 He also have the herb to cure:
(1) ALS,
(2) DIABETES,
(3) HIV&AIDS,
(4) URINARY TRACT INFECTION,
(5) CANCER,
(6) HERPES.

alisha gree said...

I was diagnose of Chronic Obstructive Pulmonary Disease (COPD) 2 years ago, my family doctor told me there is no cure but it can only be controled. Ever since then i have been running heather scepter looking for a solution to my problem because i was going to lose my Job if i dont get better, until i ran into this online testimony of Mrs Alicia who have been cured of COPD by this herbal clinic in Africa (Astoria Herbal Clinic), i immediately contacted them via their email (azentemple@gmailcom), to God be thy glory i bought this COPD herbal remedy and was cured within 3 weeks of usage, at last this is a break through for all COPD patients contact this herbal clinic via their email ( azentemple@gmailcom) or whasapp +2349038299828 He also have the herb to cure:
(1) ALS,
(2) DIABETES,
(3) HIV&AIDS,
(4) URINARY TRACT INFECTION,
(5) CANCER,
(6) HERPES.

alisha gree said...

I have been suffering from (HERPES) disease for the past 13 months and had constant pain, especially in my knees. During the first month , I had faith in God that I would be healed someday.This disease started to circulate all over my body and I have been taking treatment from my doctor, a few weeks ago I came on search on the internet if I could get any information concerning the prevention of this disease, on my search I saw a testimony of someone who has been healed from (Hepatitis B and Cancer) by this Man DR azen and she also gave the email address of this man and advise we should contact him for any sickness that he would be of help, so I wrote to DR azen telling him about my (HERPES Virus) he told me not to worry that I was going to be cured!! hmm i never believed it,, well after all the procedures and remedy given to me by this man few weeks later I started experiencing changes all over me as the DR azen me that I have cured, after 2 weeks i went to my doctor to confirmed if I have been finally healed behold it was TRUE, So friends my advice is if you have such sickness or any other like HSV1,2,HPV1,2,3,CANSER HIV,COLE SORES,TOOTH AKEA, ETC you can email DR azen on (azentemple@gmail. com) sir I am indeed grateful for the help I will forever recommend you to my friends!!! with your lovely Email Address or you can also phone/Whats App him on this number +2349038299828

alisha gree said...

I have been suffering from (HERPES) disease for the past 13 months and had constant pain, especially in my knees. During the first month , I had faith in God that I would be healed someday.This disease started to circulate all over my body and I have been taking treatment from my doctor, a few weeks ago I came on search on the internet if I could get any information concerning the prevention of this disease, on my search I saw a testimony of someone who has been healed from (Hepatitis B and Cancer) by this Man DR azen and she also gave the email address of this man and advise we should contact him for any sickness that he would be of help, so I wrote to DR azen telling him about my (HERPES Virus) he told me not to worry that I was going to be cured!! hmm i never believed it,, well after all the procedures and remedy given to me by this man few weeks later I started experiencing changes all over me as the DR azen me that I have cured, after 2 weeks i went to my doctor to confirmed if I have been finally healed behold it was TRUE, So friends my advice is if you have such sickness or any other like HSV1,2,HPV1,2,3,CANSER HIV,COLE SORES,TOOTH AKEA, ETC you can email DR azen on (azentemple@gmail. com) sir I am indeed grateful for the help I will forever recommend you to my friends!!! with your lovely Email Address or you can also phone/Whats App him on this number +2349038299828

alisha gree said...

I have been suffering from (HERPES) disease for the past 13 months and had constant pain, especially in my knees. During the first month , I had faith in God that I would be healed someday.This disease started to circulate all over my body and I have been taking treatment from my doctor, a few weeks ago I came on search on the internet if I could get any information concerning the prevention of this disease, on my search I saw a testimony of someone who has been healed from (Hepatitis B and Cancer) by this Man DR azen and she also gave the email address of this man and advise we should contact him for any sickness that he would be of help, so I wrote to DR azen telling him about my (HERPES Virus) he told me not to worry that I was going to be cured!! hmm i never believed it,, well after all the procedures and remedy given to me by this man few weeks later I started experiencing changes all over me as the DR azen me that I have cured, after 2 weeks i went to my doctor to confirmed if I have been finally healed behold it was TRUE, So friends my advice is if you have such sickness or any other like HSV1,2,HPV1,2,3,CANSER HIV,COLE SORES,TOOTH AKEA, ETC you can email DR azen on (azentemple@gmail.com) sir I am indeed grateful for the help I will forever recommend you to my friends!!! with your lovely Email Address or you can also phone/Whats App him on this number +2349038299828

Ibrahim Patricia said...

HOW DR OKOUGBE HELPED ME ENLARGE MY PENIS SIZE FROM 3.5 INCHES TO 11 INCHES LONG AND 8.0 GIRTH
hello everyone this is serious and real i want to tell the whole world about how DR OKOUGBE HERBAL MIXTURE CREAM helped me enlarge my penis size ..i have trying since 19 years of age to enlarge my penis but none rendered me the help i want i have used several vaccines,penis pump,surgery,online creams from USA SAMOA,CANADA CAMBODIA,AUSTRALIA and many more but none of them enlarge my penis i was really frustrated and tired of living because my penis was too small ,imagine a cute and handsome 38 years old man like me having 3.5 inches and to make it worse i was having erectile dysfunction which was so annoying to me,my girlfriends have left me because of my small penis ....to GOD be the glory as i was searching for help on a facebook page i saw one mr LASANTHA MADUSHANKA from italy testifying of how DR OKOUGBE HERBAL MIXTURE CREAM enlarge his penis and healed his grand mom PROSTRATE CANCER .so i quickly message him on his email i saw on the website drokougbespecialhome@gmail.com and he replied me and gave me comforting words and told me all i need to do and i was surprise he did not ask for money ,,i got his cream and he sent it to me through united parcel service (UPS)and i got it 4 days later and used the cream just as he told me and its just 5 days of using his herbal mixture my penis is now 11 inches long and 8.0 flaccidity am so happy to feel like a man in the bedroom at last so if you need penis enlargement,DIABETES 1/2 CURE,HERPES CURE,HIV/AIDS,CANCER,ALOPECIA,LUPUS DISEASE,PILE,LOW SPERM COUNT,PREMATURE EJACULATION,ERECTILE DYSFUNCTION,breast enlargement,weak erection,erectile dysfunction cure and many sexual relation cure do not hesitate to email him now drokougbespecialhome@gmail.com OR whatsapp him on +2348119278442

jolden joy said...

Happiness is all i see now I never thought that I
will be cured from HIV virus again.I have been
suffering from a deadly disease (HIV) for the past
2 years and two months now, I had spent a lot of money going
from one place to another, from churches to
churches, hospitals have been my home every day
residence.Constant checks up have been my
hobby not until this faithful day I was searching
through the internet, I saw a testimony on how
DR dodo helped someone in curing his HIV
disease, quickly I copied his contact which is just
to give him a test I spoke to him, he told me that there is no medical hospital that has the cure to HIV, i was supprise when i heard that from, he asked me to
do some certain things which I did he told me
that he is going to provide the herbal cure to me
which he did then he asked me to go for medical
checkup after some days after using the herbal
cure behold I was free from the deadly disease, he
only asked me to post
the testimony through the whole world, faithfully
am doing it now please BROTHER, SISTER,
MOTHER and FATHER he is great a great man, I
owe him in return.if you are having a similar
problem just email him Via: (drdodotemple @
gmail .com) or you can Whatsapp him Via:
( +2348147766277) HE CAN ALSO CURE
DISEASES LIKE
1*HERPES
2*DIABETICS
3*HEPATITIS B
4*CANCER,
5*GONORRHEA
Pleaseshare this round so you can also save
more souls and beware of scams Good Luck

sfp777 said...

There is so much misinformation and so many bogus products surrounding penis enlargement that when they discover the solution, no one will believe. So here goes; any male can permanently increase length and girth in the same way a bodybuilder adds mass and becomes larger. As you stress tissue, the body goes into a natural process of creating new cells making you larger. The question is not whether permanent enlargement is possible but instead, how do you safely stress penile tissue to promote cell growth? The answers can be found at MagnumRings.com

denail said...

I want to share a testimony of how Dr.Omohan herbal mixture cream saves me from shame and disgrace, my penis was a big problem to me as the size was really so embarrassing,and i was also having weak erection problem. I can't make love to my wife and my penis was just too small a full grown man like me having 4 inches penis and to worsen it i don't last in sex i cant even last two minutes it was really a thing of shame to me. My wife was really tired of me because my sex life was very poor,she never enjoyed sex,i was always thinking and searching for solutions everywhere until when i saw a testimony of how Dr.omohan herbal mixture cream have been helping people regarding their sex life, so i decided to give him a try and to my greatest surprise in less than one week of taking the herbs my penis grow to 8 inches i couldn't believe my eyes and as i speak now my penis is now 8 inches and i do not have week erection again. I can make love to my wife longer in bed. And my marriage is now stable,my wife now enjoy me very well in bed. can contact him dromohanherbalmedicine@gmail.com or call or what-apps him through +2348164816038. . .he also specialize on the following things

BREAST ENLARGEMENT
BREAST LIFT & REDUCTION
PENILE/PENIS ENLARGEMENT
GENERAL BODY SLIMMING
HIPS & THIGH REDUCTION
REGAIN VIRGINITY BACK
Thanks for the Enlarging my penis sir, you indeed save my marriage...I am really grateful sir,

denail said...

I want to share a testimony of how Dr.Omohan herbal mixture cream saves me from shame and disgrace, my penis was a big problem to me as the size was really so embarrassing,and i was also having weak erection problem. I can't make love to my wife and my penis was just too small a full grown man like me having 4 inches penis and to worsen it i don't last in sex i cant even last two minutes it was really a thing of shame to me. My wife was really tired of me because my sex life was very poor,she never enjoyed sex,i was always thinking and searching for solutions everywhere until when i saw a testimony of how Dr.omohan herbal mixture cream have been helping people regarding their sex life, so i decided to give him a try and to my greatest surprise in less than one week of taking the herbs my penis grow to 8 inches i couldn't believe my eyes and as i speak now my penis is now 8 inches and i do not have week erection again. I can make love to my wife longer in bed. And my marriage is now stable,my wife now enjoy me very well in bed. can contact him dromohanherbalmedicine@gmail.com or call or what-apps him through +2348164816038. . .he also specialize on the following things

BREAST ENLARGEMENT
BREAST LIFT & REDUCTION
PENILE/PENIS ENLARGEMENT
GENERAL BODY SLIMMING
HIPS & THIGH REDUCTION
REGAIN VIRGINITY BACK
Thanks for the Enlarging my penis sir, you indeed save my marriage...I am really grateful sir,

denail said...

I want to share a testimony of how Dr.Omohan herbal mixture cream saves me from shame and disgrace, my penis was a big problem to me as the size was really so embarrassing,and i was also having weak erection problem. I can't make love to my wife and my penis was just too small a full grown man like me having 4 inches penis and to worsen it i don't last in sex i cant even last two minutes it was really a thing of shame to me. My wife was really tired of me because my sex life was very poor,she never enjoyed sex,i was always thinking and searching for solutions everywhere until when i saw a testimony of how Dr.omohan herbal mixture cream have been helping people regarding their sex life, so i decided to give him a try and to my greatest surprise in less than one week of taking the herbs my penis grow to 8 inches i couldn't believe my eyes and as i speak now my penis is now 8 inches and i do not have week erection again. I can make love to my wife longer in bed. And my marriage is now stable,my wife now enjoy me very well in bed. can contact him dromohanherbalmedicine@gmail.com or call or what-apps him through +2348164816038. . .he also specialize on the following things

BREAST ENLARGEMENT
BREAST LIFT & REDUCTION
PENILE/PENIS ENLARGEMENT
GENERAL BODY SLIMMING
HIPS & THIGH REDUCTION
REGAIN VIRGINITY BACK
Thanks for the Enlarging my penis sir, you indeed save my marriage...I am really grateful sir,

denail said...

I want to share a testimony of how Dr.Omohan herbal mixture cream saves me from shame and disgrace, my penis was a big problem to me as the size was really so embarrassing,and i was also having weak erection problem. I can't make love to my wife and my penis was just too small a full grown man like me having 4 inches penis and to worsen it i don't last in sex i cant even last two minutes it was really a thing of shame to me. My wife was really tired of me because my sex life was very poor,she never enjoyed sex,i was always thinking and searching for solutions everywhere until when i saw a testimony of how Dr.omohan herbal mixture cream have been helping people regarding their sex life, so i decided to give him a try and to my greatest surprise in less than one week of taking the herbs my penis grow to 8 inches i couldn't believe my eyes and as i speak now my penis is now 8 inches and i do not have week erection again. I can make love to my wife longer in bed. And my marriage is now stable,my wife now enjoy me very well in bed. can contact him dromohanherbalmedicine@gmail.com or call or what-apps him through +2348164816038. . .he also specialize on the following things

1. HIV / AIDS
2. HERPES 1/2
3. CANCER
4. ALS (Lou Gehrig's disease)
5. Hepatitis B
6. chronic pancreatic
7. emphysema
8. COPD (chronic obstructive pulmonary disease)
Thanks for the Enlarging my penis sir, you indeed save my marriage...I am really grateful sir,

denail said...

I want to share a testimony of how Dr.Omohan herbal mixture cream saves me from shame and disgrace, my penis was a big problem to me as the size was really so embarrassing,and i was also having weak erection problem. I can't make love to my wife and my penis was just too small a full grown man like me having 4 inches penis and to worsen it i don't last in sex i cant even last two minutes it was really a thing of shame to me. My wife was really tired of me because my sex life was very poor,she never enjoyed sex,i was always thinking and searching for solutions everywhere until when i saw a testimony of how Dr.omohan herbal mixture cream have been helping people regarding their sex life, so i decided to give him a try and to my greatest surprise in less than one week of taking the herbs my penis grow to 8 inches i couldn't believe my eyes and as i speak now my penis is now 8 inches and i do not have week erection again. I can make love to my wife longer in bed. And my marriage is now stable,my wife now enjoy me very well in bed. can contact him dromohanherbalmedicine@gmail.com or call or what-apps him through +2348164816038. . .he also specialize on the following things

1. HIV / AIDS
2. HERPES 1/2
3. CANCER
4. ALS (Lou Gehrig's disease)
5. Hepatitis B
6. chronic pancreatic
7. emphysema
8. COPD (chronic obstructive pulmonary disease)
Thanks for the Enlarging my penis sir, you indeed save my marriage...I am really grateful sir,

denail said...


I want to share a testimony of how Dr.Omohan herbal mixture cream saves me from shame and disgrace, my penis was a big problem to me as the size was really so embarrassing,and i was also having weak erection problem. I can't make love to my wife and my penis was just too small a full grown man like me having 4 inches penis and to worsen it i don't last in sex i cant even last two minutes it was really a thing of shame to me. My wife was really tired of me because my sex life was very poor,she never enjoyed sex,i was always thinking and searching for solutions everywhere until when i saw a testimony of how Dr.omohan herbal mixture cream have been helping people regarding their sex life, so i decided to give him a try and to my greatest surprise in less than one week of taking the herbs my penis grow to 8 inches i couldn't believe my eyes and as i speak now my penis is now 8 inches and i do not have week erection again. I can make love to my wife longer in bed. And my marriage is now stable,my wife now enjoy me very well in bed. can contact him dromohanherbalmedicine@gmail.com or call or what-apps him through +2348164816038. . .he also specialize on the following things

1. HIV / AIDS
2. HERPES 1/2
3. CANCER
4. ALS (Lou Gehrig's disease)
5. Hepatitis B
6. chronic pancreatic
7. emphysema
8. COPD (chronic obstructive pulmonary disease)
Thanks for the Enlarging my penis sir, you indeed save my marriage...I am really grateful sir,

denail said...


I want to share a testimony of how Dr.Omohan herbal mixture cream saves me from shame and disgrace, my penis was a big problem to me as the size was really so embarrassing,and i was also having weak erection problem. I can't make love to my wife and my penis was just too small a full grown man like me having 4 inches penis and to worsen it i don't last in sex i cant even last two minutes it was really a thing of shame to me. My wife was really tired of me because my sex life was very poor,she never enjoyed sex,i was always thinking and searching for solutions everywhere until when i saw a testimony of how Dr.omohan herbal mixture cream have been helping people regarding their sex life, so i decided to give him a try and to my greatest surprise in less than one week of taking the herbs my penis grow to 8 inches i couldn't believe my eyes and as i speak now my penis is now 8 inches and i do not have week erection again. I can make love to my wife longer in bed. And my marriage is now stable,my wife now enjoy me very well in bed. can contact him dromohanherbalmedicine@gmail.com or call or what-apps him through +2348164816038. . .he also specialize on the following things

1. HIV / AIDS
2. HERPES 1/2
3. CANCER
4. ALS (Lou Gehrig's disease)
5. Hepatitis B
6. chronic pancreatic
7. emphysema
8. COPD (chronic obstructive pulmonary disease)
Thanks for the Enlarging my penis sir, you indeed save my marriage...I am really grateful sir,

jolden joy said...

Hi everybody. I recently saw a testimony about dr john soco, in a blog I visit for relationship and dating counseling problems because i had been having serious issues with my boyfriend and we had been dating for six months, he just suddenly changed, he wasn't returning my calls,he started cheating,he was hurting me in many ways i never thought possible and I just thought I should try it*maybe out of desperation of some sort*..and I contacted dr john soco, ..At first everything felt dreamy and unbelievable, his consultations and solution was a little bit easy and strange and I was scared a little cause I heard read and heard lots of stories of fake spell casters,scams and i never really believed in magic..I played along with a little hope and and faith and I sent some few stuffs after everything and it worked like a miracle,everything went to a while new direction,it was and is amazing...I guess it was all good faith that made me read That particular post that faithful day..I hope he could help other people too like he did me...I did a little and I got everything I wanted and wished for*my husband,my family and my life back. E-mail: drjohnsoco@gmail.com or drjohnsoco@outlook.com, contact him on whats App him +2348147766277

Charles Richardson said...

My name is darrell Browne I want to say a big thanks to Dr kadima for the good job he has done for me, after taking his product today my sexual life is health and balance am now living up to my wife expectation. For the past 7 years i have been struggling with weak erection and premature ejaculation. I have spend money on it but no cure until I took this product, just within few days i got cured. He also cure other illnesses, you can email him on Doctorkadima522@gmail.com or Whats-app him on +2347054553379...

rosesharon said...

Herpes is a serious and recurring disease which can't be cured through drugs or injections by the American doctors but the best way to deal with Herpes is by taking natural herbs medicine for it, I have read about DR EDIDIA the great herbalist doctor who cure me from herpes with his powerful herbal medicine. i contacted him to know how he can help me and he told me never to worry
that he will help me with the natural herbs from God!
after 2 days of contacting him, he told me that the cure has been ready and
he sent it to me via UPS SPEED POST and it got to me after 3 days!
i used the medicine as he instructed me (MORNING and EVENING) and i was
cured!
its really like a dream but i am so happy! for the people suffering from the following diseases, Cancer, hypothyroidism, Herpes, COPD, HIV, Arthritis, Hpv, Infections,Liver Disease, Autoimmune Diseases, Parkinson's disease,Lupus and more should contact him for his herbal medicine because i am a living testimony and i was cured of herpes and his medicine is legit. i sent him what he requested and he sent me his medicine which i took for 3 good weeks and today am out here with negative result. when i went for test i was so happy after going through his medication. you can reach him through his email dredidiaherbalhome@gmail.com or call whatsapp number:+2349074505296 he will help you out. here is the Dr website http://dredidiaherbalhome.weebly.com/
https://dr-edidia-herbal-home.business.site/ https://naturaltreatmentherpes.blogspot.com/ https://besherpestreatment.blogspot.com/

I,m rosesharon and you can get intouch with me via rosesharon915@gmail.com also view website to know him.

Salami Faith said...

I am here to give my testimony about Dr Destiny for his marvelous work in my life, I was diagnosed of Herpes Virus since over a month now and I was taking my medications, I wasn't satisfied i needed to get the Herpes virus out of my system, I searched about some possible cure for Herpes i saw a comment about Dr Destiny,how he cured Herpes with his herbal medicine, I contacted him and he guided me. I asked for solutions, he started the remedy for my health, he sent me the medicine through UPS office I took the medicine as prescribed by him and 14 days later i was cured from Herpes ,thank you for anyone that may need the medication you can contact him for your urgent cure

EMAIL: drdestinyspellhome@gmail.com
WHATSAPP +2348105074556

Salami Faith said...

Cancer is a serious and recurring disease which can't be cured through drugs or injections by the American doctors but the best way to deal with Cancer is by taking natural herbs medicine for it and is only few American doctors that know about this herbal medicine from Dr Destiny. I have read about Dr Destiny the great herbalist doctor from African who can cure disease with his powerful herbal medicine. for the people suffering from the following diseases, Cancer, hypothyroidism, HERPES, HIV, LUPUS, HEPATITIS, DIABETES, HPV, Infections ETC should contact him for his herbal medicine because i am a living testimony and i was cured of Cancer. . Although, i sent him what he requested and he sent me his medicine which i took for 3 good weeks and today am out here with negative result. when i went for test i was tested Cancer negative after going through his medication. you can reach him through his email: ( drdestinyspellhome@gmail.com ) or call whatsapp number:+2348105074556 he will help you out.

denail said...

I would like to let all know that the size of your Penis really matters in your relationship or marriage. I got married to my wife about 1 month after we met on a photo studio, we lived happily for the first 3 months of our marriage until i and my wife started having quarrels at home because i couldn't satisfy her on bed with my little penis. Actually my penis was very small, it measured about 4.5 inch long on erection and i am 39 years old. My wife said it was forbidden by the women of this world. My wife started sleeping with other men outside. Sometimes i will return from work without finding my wife at home and whenever i call or ask her where she was, she will always snub at me and sometimes just tell me to go get a larger dick. All this continued for a long time and it hurt me so much that i was at the edge of breaking up on the marriage till when i read about a doctor called DR.OMOHAN. online. I never thought i could smile and be in a happy marriage again if not for the help of DR.OMOHAN. I got the doctors Emails:(dromohanherbalmedicine@gmail.com ) on the internet and i emailed him, and he got back to me with some encouraging words, he got me some herbs cream which i use for just 8 days and i began to feel the enlargement of my penis, and without surgery. This went on for a little period of about 10 days and to my surprise my wife keeps screaming that she love my big dick now. Now my wife no longer cheat on me, and my penis is now about 10.5 inches long on erection and off course very large round. And now my wife uses breasts, hips and bums enlargement. I and my wife are very happy for the help rendered to me by DR.OMOHAN , and i want to say a big thanks to Doctor for the help. You can contact the Doctor now on his Email:( dromohanherbalmedicine@gmail.com ) Am thankful to the doctor for helping me.
his whataspp number +2348164816038

DOCTOR OMOHAN CAN AS WELL HELP THE FOLLOWING PROBLEMS
1. HIV/AIDS SPELL
2. HERPES SPELL
3. CANCER SPELL
4 IF YOU WANT YOUR EX LOVER BACK SPELL
5 IF YOU NEED A BABY SPELLhim to solve
6 LOW SPERM COUNT SPELL
get all your problem solve. No problem is too big for him to solve.

Mark Kingston said...

Are you paying $189 a week for Valtrex or $67 for Acyclovir to suppress your outbreaks? Have you considered your yearly prescription costs for these drugs, $2000+ a year! Anyone who has herpes can attest to the painful and embarrassing symptoms. Unfortunately, many find that doctor recommended products are frequently not effective at taking care of the problem.DR OHIKHOBO herbal remedy will get to the root of the cause and cure you completely rather than suppress outbreaks with medication. and leave you happier, healthier, and outbreak FREE!.let my tell you all how i was cured completely from herpes.at first i never believed i could be cure considering all type of of medication i have been using but it all came like dream come true for me that i was able to be cured by DR OHIKHOBO herbal remedy as I speak now I have no more outbreaks,.It could change your life.contact DR OHIKHOBO at drohikhoboherbalcenter@gmail.com or you can reach him through his whatssap at +2348103601042.

john danilla said...

I am John Danilla from UK( northern ireland), i want to share a
testimony on how a powerful spell caster cured my HIV disease, i was
diagnosed of this disease, in the year 2009, last week i saw a testimony on
Dr.Akioya on how he cured an HIV patient, so i contacted him through phone
and he asked me to email him, which idid, so he told me that all my
problems is over and then he decided to do an healing spell spell for me so
after he finished it, he told me to wait for just 24 hours and then i
should go for a test, so i really did as he had said, so my greatest
surprised when i went to the hospital to go for an HIV test, the Medical
doctor diagnosed that, i am now HIV negetative at first i was amazed and
now i have come to realise that this spell caster Dr. Akioya is a very
powerful one and a real spell caster. So viewers of this should please join
me in my celebration for i am the happiest man on earth today and if you
want to contact him, you can do this via his email
(drakioya17spellhome@gmail.com or call him or whatsapp him
+2348105257464. or you can visit is website;
http://drakioyaherbalcenter.home.blog
https://drakioyaherbalhome.blogspot.com/

ben mark said...

Hello everyone i Am Ben Mark and i am from USA i am here to give my testimony about an herbal doctor called Dr,Akioya I was heartbroken because i had very small penis,not nice to satisfy a woman, i have been in so many relationship, but cut off because of my situation, i have used so many product which doctors prescribe for me, but could not offer me the help i searched for. i saw some few comments on the internet about this specialist called Dr,Akioya and decided to email him on his email i saw on the internet,(drakioya17spellhome@gmail.com ) so I decided to give his herbal product a try. i emailed him and he got back to me, he gave me some comforting words with his herbal product for Penis Enlargement, Within three weeks of me use it, i began to feel the enlargement, " and now it just 4 weeks of using his products my penis is about 8 inches longer, and i had to settle thing out with my ex girlfriend , i was surprised when she said that she is satisfied with my performance in bed and i now have a large penis.thanks to DR Akioya for is herbal product. you can also reach him with emsil drakioya17spellhome@gmail.com though is..number WHATASPP him today on this number [ +2348105257464 ] you can checkout is website; http://drakioyaherbalcenter.home.blog
https://drakioyaherbalhome.blogspot.com/

ben mark said...

Hello everyone i Am Ben Mark and i am from USA i am here to give my testimony about an herbal doctor called Dr,Akioya I was heartbroken because i had very small penis,not nice to satisfy a woman, i have been in so many relationship, but cut off because of my situation, i have used so many product which doctors prescribe for me, but could not offer me the help i searched for. i saw some few comments on the internet about this specialist called Dr,Akioya and decided to email him on his email i saw on the internet,(drakioya17spellhome@gmail.com ) so I decided to give his herbal product a try. i emailed him and he got back to me, he gave me some comforting words with his herbal product for Penis Enlargement, Within three weeks of me use it, i began to feel the enlargement, " and now it just 4 weeks of using his products my penis is about 8 inches longer, and i had to settle thing out with my ex girlfriend , i was surprised when she said that she is satisfied with my performance in bed and i now have a large penis.thanks to DR Akioya for is herbal product. you can also reach him with emsil drakioya17spellhome@gmail.com though is..number WHATASPP him today on this number [ +2348105257464 ] you can checkout is website; http://drakioyaherbalcenter.home.blog
https://drakioyaherbalhome.blogspot.com/

Relanes Ihab said...

Hello viewers around the Globe, I was despondent because i had a very small penis, about 2.5 inches soft and 4 inches hard not nice enough to satisfy a woman, i have been in so many relationship, but cut off because of my situation, i have used so many product which doctors prescribe for me, but none could offer me the help i searched for. i saw some few comments on the internet about this specialist called Dr, OLHIA and i decided to contact him on his {oliha.miraclemedicine@gmail.com} so I decided to give his herbal product a try. i emailed him and he got back to me, he gave me some comforting words with his herbal pills for Penis Enlargement, Within 3 week of it, i began to feel the enlargement of my penis, " and now it just 4 weeks of using his products my penis is about 9 inches longer, and i had to settle out with my Ex girlfriend Ella, i was surprised when she said that she is satisfied with my sex and i have got a large penis. Am so happy, thanks to Dr OLIHA I also learn that Dr OLIHA also help with Breast Enlargement Hips and Bums Enlargement etc.. If you are in any situation with a little Penis, weak ejaculation, small breast_hips_bums do get to Dr OLIHA now for help on his email {oliha.miraclemedicine@gmail.com} or whats app him number: +2349038382931

JAMIE HARRY PAUL said...

hello everyone i am jamie harry from texas USA i want to tell the whole world of great dr obue herbal mixture i was unhappy ever since my girlfriend back then in college mocked me of having a small penis and weak in bed ,ever since then i have been trying to improve my sex life but all effort failed ..but it gut worse when i got married ,my wife is so angry with me and Threatened to leave me if i do not find a way and i love my wife so much so one faithful day i was reading some comments on a blog then i saw a comment of one MR GERARD PETE FROM new Orleans testifying of how dr obue helped him enlarge his penis and fertilise his sperm count so i quickly contacted him by his website link https://drobuesolutiontemp.wixsite.com/drobue and he got back to me and i did as he said ..to my greatest surprise i got 10 inches within two weeks of using his herbal medicine and now its just 3 weeks i am having 10.5 inches i am so happy now..my wife told me am so good in bed that i almost killed her last night all thanks to him note he also cure sicknesses and diseases like PENIS ENLARGEMENT ERECTILE DYSFUNCTION DIABETES type 1 and type 2 HERPES GENITAL WART LOW SPERM COUNT WEAK ERECTION BREAST ENLARGEMENT PROSTRATE CANCER HIV/AIDS PREMATURE EJACULATION so if you need his help contact him on his email drobuesolutiontemple@gmail.com visit his site https://drobuesolutiontemp.wixsite.com/drobue or whatsapp him on +2348030569449 thanks

katrina sharon said...


BEST TRADITIONAL HERBAL CURE FOR KIDNEY DISEASE AND CANCER .Hi Friends i am so glad to write this article today to tell the
world how my KIDNEY DISEASE was cured,i have been detected with kidney disease (CKD), ever since then my life has
been in complete bizarre and agony,i have used so many
drugs that was prescribed to me by several doctors,but it
didn't cure my kidney disease (CKD) neither did it reduce the pain,until a
certain day i was checking for solution in the internet,then
miraculously came across Dr. Edidia the powerful herbalist
that cure numerous individuals KIDNEY DISEASE AND CANCER then i
contacted his email:
( dredidiaherbalhome@gmail.com and his what'sap number +2349074505296) i explained everything to
him and prepared a cure and send it to me that cure my kidney disease totally
after receiving his herbal medicine, he also cure my friend from CANCER DISEASE so my friends viewer
so why wait and suffer when there is someone like Dr Edidia
that can cure any disease kidney disease, hpv, als, Cardiovascular disease (CVD), Coronary heart disease, herpes, how, cancer.
you can contact via email:
( dredidiaherbalhome@gmail.com) or whatsapp him.
+2349074505296
his website http://dredidiaherbalhome.weebly.com/
https://dr-edidia-herbal-home.business.site/

Michelle Buff said...

Hello everyone. Dr.DADA Herbs is a good remedy for herpes Virus , I was a carrier of herpes virus and I saw a testimony on how Dr. DADA cure Herpes Virus, I decided to contact him, I contacted him and he guided me. I asked him for solutions and he started the remedies for my health. After he finish he sent me the herbs which i took for 2 weeks before asking me to go for a check up and getting there i could not believe that i was confirm HSV 2 Negative after the test,Today i am so happy because i'm free from herpes disease with the help of Dr. DADA Thank God now everything is fine, I'm cured by Dr. DADA herbal medicine, I'm very thankful to God for making it possible. you can reach him on his email, i strongly recommend him to any one out here looking for a cure . (drdadaspellhome7@gmail.com) or (drdadaspellhome@hotmail.com) You can also /whatsapp him +2348158568638